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#6 - University of Pittsburgh
Fiscal 2013 NIH funding: $396.73 million
Fiscal 2012 NIH funding: $430.03 million
Change in funding: -$33.3 million
Number of awards in 2013: 963
Number of awards in 2012: 1,012
At the end of last year, researchers at the University of Pittsburgh School of Public Health launched Project Tycho, an initiative that has turned 88 million disease cases published in the Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report into an open-access database. So far, the team has used the database to show how the introduction of vaccines affected rates of polio, measles, rubella and other now-preventable diseases. "We've taken this entire corpus of the infectious disease history and made it so anybody on earth can look at it easily, conveniently and make sense out of it," University of Pittsburgh's Dr. Donald Burke said in a previous statement.
In a discovery in early 2013, investigators at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine identified a molecule that polices lung infection in tuberculosis. They found that granulomas that contain ectopic lymphoid structures, which resemble lymph nodes, are associated with effectively suppressing TB. On the other hand, granulomas that don't contain them are associated with active TB. They linked a surface marker molecule called CXCR5 on T cells with the presence of ectopic lymphoid structures.
Also last year, in collaboration with researchers from the Mount Sinai Medical Center, University of Pittsburgh investigators discovered a novel mechanism that regulates the replication of insulin-producing beta cells in the pancreas, a finding that could have implications for treating both Type 1 and Type 2 diabetes.
Digitization work turns 125 years of disease reports into Big Data goldmine