53. Motegrity

shire
(Shire)

Active ingredient: prucalopride
Disease: chronic idiopathic constipation
Peak sales estimate: n/a
Approved: Dec. 17
Company: Shire

The scoop: Synergy Pharmaceuticals wasn’t able to seriously challenge Allergan’s Linzess in the market with Trulance, but now Shire is going to give it a try. It’ll be wielding Motegrity, a constipation treatment that works by stimulating muscle movement in the colon. Regulators OK’d the drug after an advisory panel endorsed it unanimously, voting 10-0 in favor of an approval and signaling its satisfaction with Shire data showing the drug didn’t come with the same cardiovascular safety risks as other products in its class of 5-HT4 treatments. The green light was also a win for Takeda, which will soon swallow Shire as part of a $62 billion buyout, and it should bring a little peace of mind to some Takeda investors that opposed the deal. — Carly Helfand

 

53. Motegrity

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