18. Mektovi/Braftovi

mektovi
(Array BioPharma)

Active ingredient: binimetinib/encorafenib 
Disease: BRAF-mutated melanoma 
Peak sales estimate: n/a 
Approved: June 27 
Company: Array BioPharma 

The scoop: Array BioPharma had to pull the NDA for binimetinib in March 2017 after it failed as a solo therapy for NRAS-mutant melanoma. But the MEK inhibitor turned out to be a winner in combination with BRAF inhibitor encorafenib. The combination nearly doubled survival compared to Roche’s Zelboraf in a pivotal trial of melanoma with BRAF mutations. The FDA approved the Mektovi/Braftovi combination for the treatment of patients with melanoma that can't be surgically removed or has spread through the body, provided the tumors have BRAF V600E or V600K mutations. The treatment is competing with combos from pharma heavyweights Novartis and Roche, but Array CEO Ron Squarer thinks the company’s small size will give it a leg up. "As a smaller company, we are excited about working to make the patient experience as good as possible," he said, adding that there's a "very concentrated group of prescribers," so the small biotech will be able to cover the ground with a small field force. — Amirah Al Idrus

18. Mektovi/Braftovi
Read more on

Suggested Articles

Spring Bank’s hepatitis B drug, given in tandem with Gilead’s Vemlidy, tamped down on chronic disease in 23% of patients in a phase 2 study.

Gilead names Dickinson to CFO role; MedImmune CSO Herbst nabs CSO job at Pyxis; Checkmate picks up Wooldridge for CMO.

The readout is a key moment in the history of the drug and Mirati, shares in which have soared in the updraft created by data on Amgen’s rival asset.