Stroke drug cocktail normalizes brain fluids, restores movement in mice

head and brain
Researchers led by the Riken Center for Brain Science in Japan are reporting that adrenergic receptor antagonists normalize the brain's fluid exchange and potassium levels in mouse models of stroke. (American Heart Association)

Adrenergic receptor (AdR) antagonists work by counteracting electrical and chemical disturbances in the brain. New research in mouse models suggests that a cocktail of these drugs may reduce the spread of tissue damage and aid in recovery.

Researchers led by the Riken Center for Brain Science in Japan administered AdR blockers to mice following a stroke and observed fluid in the brain, which can accumulate and lead to damaging swelling. They discovered that the drugs normalized fluid exchange and helped level out potassium in the animals’ brains.

Mice that received the drugs were able to regain the use of their front legs more quickly than animals that were not treated, the researchers reported in the journal Proceedings of the National Academy of Sciences.

Free Webinar

From Patient Adherence to Manufacturing Ease - Why Softgels Make Sense for Rx

Join Thermo Fisher Scientific’s upcoming webinar to learn why softgels offer numerous benefits for Rx drug development, including enhanced bioavailability, patient compliance and easy scale-up. Register Today.

"We know that the water dynamics in the brain immediately during and after a stroke are critical, so we focused on the pathways that move fluids in and out of cells," said lead author Hiromu Monai in a statement.

Specifically, they zeroed in on a fluid channel called aquaporin-4, the levels of which fall following a stroke. They hypothesized that aquaporin-4 is critical to protecting the brain during a stroke. To prove it, they took mice that had been genetically engineered to lack the fluid channel and treated them with AdR blockers. Their brain potassium levels stayed high, and they showed no benefits from the treatment, the team reported.

RELATED: Acticor's blood thinner cuts hemorrhage risk in human study, could offer hope for acute stroke

Several research groups are exploring different strategies for reducing brain swelling after a stroke. Last year, for example, a team at the Medical University of South Carolina described a compound that tamped down the immune response to stroke in mice, lowering inflammation in their brains without negatively affecting immune functions throughout the rest of the body.

Biogen bet $335 million last year on TMS’ plasminogen activator, which breaks down blood clots after strokes and inhibits inflammation in the brain.

The Riken researchers have applied for a patent for their AdR treatment, they said. "Keeping potassium levels in balance is an alternative therapeutic strategy for stroke, and we found that adrenergic receptor blockers promote this normalization," Monai said.

Suggested Articles

A COVID-19 antibody diagnostic developed through a joint venture between Mount Sinai Health System and RenalytixAI has been authorized by the FDA.

Researchers at Northwestern University have trained an AI algorithm to automatically detect the signs of COVID-19 on a basic X-ray of the lungs.

Polyphor is developing an inhaled version of murepavadin, which targets Pseudomonas aeruginosa infections, but is currently given intravenously.