Karyopharm’s PAK4 blocker overcomes resistance to immuno-oncology drugs in mice
Drugs that inhibit the immune checkpoint PD-1, such as Keytruda, have revolutionized the treatment of many cancers, but some patients become resistant to them. A study from the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, could point to new strategies for overcoming immuno-oncology resistance. The UCLA researchers studied biopsies from people with melanoma who received Keytruda and discovered that non-resistant tumors exhibited high expression of the gene PAK4. When they inhibited PAK4 in mice using Karyopharm’s investigational drug KPT-9274, they observed an increase in tumor-specific immune cells and a subsequent reversal of resistance to PD-1 blockade. They published the results in the new journal Nature Cancer. (Release)
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Could CAR-T loaded on metal strips fight solid tumors?
Personalized treatments known as CAR-T cells are on the market to treat blood cancers, but the technology has been difficult to adapt to solid tumors. Scientists at the Fred Hutchinson Cancer Research Center have come up with a new way to deliver CAR-T to tumors. It's a mesh scaffold, about seven times thinner than a human hair, that's made from the same metal used in stents, bone repair and braces to straighten teeth. In a study published in Nature Biomedical Engineering, the researchers described their technique, which involves loading CAR-T cells onto the mesh and implanting them on tumors. They reported that in mouse models of ovarian cancer, the treatment caused tumors to disappear in 10 days. (Release)