How camels and llamas are inspiring new treatments for cancer, MS and more

Scientists are drawing inspiration from camels to develop antibodies against cancer-causing enzymes.

Metalloproteinases (MMPs) are enzymes in the body that are critical to tissue regeneration and other normal processes. But when MMPs are overly abundant, cancer can grow and spread. And faulty MMPs have been implicated in a range of other diseases, including asthma, multiple sclerosis and Alzheimer’s.

Now researchers at the University of California at Riverside are developing monoclonal antibodies that can bind to abnormal MMPs without affecting healthy versions of the enzymes. Their inspiration: camelids, a family of animals that includes camels and llamas.

Camelids have naturally occurring antibodies that may help solve one of the fundamental challenges of developing highly specific MMP inhibitors. The binding sites of both MMPs and most human antibodies are buried, making it difficult to get them to stick together, explained Xin Ge, an assistant professor of chemical and environmental engineering at Riverside and a lead researcher on the project in a press release.


Like this story? Subscribe to FierceBiotech!

Biopharma is a fast-growing world where big ideas come along every day. Our subscribers rely on FierceBiotech as their must-read source for the latest news, analysis and data in the world of biotech and pharma R&D. Sign up today to get biotech news and updates delivered to your inbox and read on the go.

Camelid antibodies, on the other hand, have a “convex,” a looped binding site that makes them stickier than human antibodies. Giving camelid antibodies directly to people would likely cause dangerous immune responses, so Ge’s team synthesized human-like antibodies with convex loops. So far, dozens of the experimental antibodies have proven effective at reducing the spread of cancer in rodents, according to the release. The research was published in the journal Proceedings of the National Academy of Sciences.

Oncology researchers have tried a variety of methods for blocking faulty MMPs, but they’ve frequently failed to do so without also affecting normal MMPs and causing side effects. "Clinical trial failures have taught us that selective, rather than broad-based, inhibitors are required for successful MMP therapies,” Ge said in the release.

Gilead is one company that’s having mixed success with an MMP-inhibiting antibody. The experimental drug, GS-5745, failed in ulcerative colitis, prompting the company to abandon a phase 2/3 trial in September. Gilead continues to test the compound in Crohn’s disease, as well as in gastric cancer, where it is in a phase 3 trial in combination with Bristol-Myers Squibb’s checkpoint inhibitor Opdivo (nivolumab).

MMPs are also being investigated for their potential in cancer detection. In 2014, a group of German scientists described nanoparticles they’ve created that can target MMPs in cancer and make them more visible in MRI scans.

Suggested Articles

By employing heart rate signals, physical activity and sleep quality, common Fitbit trackers may be able to predict the spread of the flu.

Nanox has raised $26 million to help fuel the development and commercialization of its Star Trek-inspired digital X-ray bed.

Oncology is clearly a major medical and societal issue, but one that sees too much focus from biopharmas at the expense of other killers.