Aileron snags $12M to fuel first human study of 'stapled' peptide

After 8 years of patient R&D work, Aileron Therapeutics has banked a $12 million tranche from its lineup of investors--which includes four Big Pharma venture groups--to back the first-ever human study of a stapled peptide. The tranche lifts Aileron's Series D, initially announced in 2009, to $42 million.

Aileron's technology "staples" peptides into a biologically potent structure that can penetrate cells, creating stable proteins that can be used to go after a slate of tough targets. Their first human study will be a Phase I trial for orphan endocrine disorders. The current investors--Apple Tree Partners, Excel Venture Management, Lilly Ventures, Novartis Venture Funds, Roche Venture Fund and SR One--put up the cash, drawn by the notion that stapled peptides could represent a new class of frontline therapies for serious diseases.

"These proceeds will allow us to advance ALRN-5281 through Phase I development and continue to develop our pipeline of Stapled Peptide drugs," Joseph A. Yanchik III, president and chief executive officer of Aileron Therapeutics, said in a release. "This is a critical next step for our company, our collaborators and the emerging Stapled Peptide field."    

Aileron--a 2009 Fierce 15 company--nailed a high-profile, $1.1 billion development pact with Roche ($RHHBY) in 2010 which includes a focus on a dual inhibitor of MDM2 and MDMX for p53-dependent cancers.

- here's the press release

Special Report: Aileron Therapeutics - 2009 Fierce 15

Related Articles:
Stapled peptides 'herald a new era' for pharma
'Stapled peptides' still the talk of the town
Roche staples together Aileron deal worth up to $1.1B
Big Pharma venture groups join $40M Aileron round

Suggested Articles

Fifteen of the 22 patients in a gene therapy trial no longer needed transfusions, while the remainder needed fewer transfusions.

Argos Therapeutics is ending its kidney cancer trial and mulling options, including a merger or sale, to stay alive.

CNS Pharma says berubicin is the first anthracycline drug to cross the blood-brain barrier and could transform treatment of the highly invasive brain tumor.