Spotlight On... Cardiac Dimensions touts post-market study of its transcatheter mitral valve repair device; Google parent Alphabet should buy AIG?; Materialise debuts 3-D printing products for hospitals; and more...

Kirkland, WA's Cardiac Dimensions touted a post-market, observational study of 17 patients of its CE-marked Carillon transcatheter mitral valve repair device. All but one of the "real world" patients were able to receive the device, which is deployed through the neck's jugular vein, enabling a beating heart procedure instead of open heart surgery. Moreover, the Carillon reduced mitral regurgitation, and additional improvement was seen after three months, according to the Journal of Invasive Cardiology. The Carillon is designed to treat functional (as opposed to degenerative) mitral regurgitation by reducing the size of the annulus. A study in the New England Journal of Medicine found that mitral valve replacement is superior in patients with that form of the disease, but company vice president Omari Bouknight said in an interview that the paper studied surgical devices only, not minimally invasive transcatheter ones. Plus, surgical mitral valve replacements have not yet overcome significant safety and engineering challenges, leaving repair as the only commercially available transcatheter option for the mitral valve. Cardiac Dimensions has received reimbursement in Germany, Turkey and Saudi Arabia. It plans to file for FDA permission to conduct U.S. clinical trials this year, Bouknight said. Meanwhile, competitor Mitralign just received a CE mark for its transcatheter repair device that's also aimed at treating the functional form of mitral regurgitation. More | Here's the study

@FierceMedDev: ICYMI yesterday: ResMed to offer its customers software-based services thanks to $800M purchase of Brightree. Article | Follow @FierceMedDev

@StacyALawrence: ICYMI: Philips unveils wearable, wireless vitals patch that goes from hospital to home. Report | Follow @StacyALawrence

@EmilyWFierce: Two Texas hospitals said that they've developed a rapid test for Zika. More from Reuters | Follow @EmilyWFierce

> Materialise ($MTLS) is rolling out a suite of software and solutions aimed at better integrating 3-D printing into the hospital. More

> A Citigroup analyst makes the case that Google parent Alphabet ($GOOG) should buy insurance giant AIG. More

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Biotech News

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@DamianFierce: this is Damien Hirst's new restaurant. More | Follow @DamianFierce

> Google backs $75M A round for Stanford's immuno-oncology spinout Forty Seven. Report

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Pharma News

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@EricPFierce: EMA takes aim at another China API producer with manufacturing problems. More from FiercePharmaManufacturing | Follow @EricPFierce

@CarlyHFierce: Allergan pooh-poohs threat from Shire's prospective dry-eye drug. FiercePharmaMarketing story | Follow @CarlyHFierce

> Werner Baumann takes top Bayer job May 1 as Marijn Dekkers exits. News

> Zepatier beats Harvoni, Sovaldi in hep C clinical-data safety showdown: Advera Health Analytics. Article

Biotech Research News

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Vaccines News

> Philippines' immunization program for Sanofi's Dengvaxia set to start in April. More

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> Researchers create first 3-D 'map' of malaria parasite protein. Item

> Brazil funds dengue vaccine PhIII, report says. Article

Pharma Marketing News

> Allergan pooh-poohs threat from Shire's prospective dry-eye drug. Report

> Bayer sees its new Kovaltry as one arrow in a hemophilia quiver. Story

> Will pharma advertisers pay the price for Google's pared-down search pages? More

> WebMD sees rapid online and mobile growth in pharma ads, with more to come. Article

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