K2M files a stealthy IPO; Claret gets a CE mark; LifeCell goes shopping at a Silicon Valley med tech incubator;

@FierceMedDev: U.K. researchers unveil an artificial pancreas they've been developing for 20 years. News | Follow @FierceMedDev

@MichaelGFierce: St. Jude places its first Nanostim leadless pacemaker in a U.K. patient. Story | Follow @MichaelGFierce

@EmilyWFierce: Johnson & Johnson's Animas launches new combination insulin pump in Canada. Article | Follow @EmilyWFierce

@GalenMoore: Pfizer misses its endpoint for 2 PhIII trials of dacomitinib in non-small cell lung cancer. Release | Follow @GalenMoore

> Virginia-based spinal surgery company K2M has submitted a confidential IPO under the SEC's new filing rules for emerging growth companies. The S-1 is still under wraps, but you can read the company's brief announcement.

> Claret Medical gets a CE mark for its Sentinel system to protect the brain during surgery. Announcement

> LifeCell Corp. has snapped up an advanced adipose tissue injector from med tech incubator TauTona Group. Release

> Contract diagnostics outfit ResearchDx is expanding into the Middle East. The announcement came at the Arab Health Congress in Dubai, which starts today. Release

> ENeura has filed for FDA 510(k) approval of its SpringTMS migraine treatment. Release

> Celsion Corp. has new survival results from its PhIII HEAT study of ThermoDox in primary liver cancer. Release

> OncoCyte Corp., a BioTime subsidiary, has started up clinical development of a bladder cancer diagnostic test in the U.S. and China. Announcement

Biotech News

@FierceBiotech: Is Bristol-Myers fading back in its hot race with Merck for PD-1 lead? More | Follow @FierceBiotech

@JohnCFierce: Scoff warning: This buyout story relates to experimental dendritic cell cancer vaccine tech. Story | Follow @JohnCFierce

@DamianFierce: ICYMI: Big-time pharma contractor Catalent lines up for an IPO worth $100M--or much more. Article | Follow @DamianFierce

@EmilyMFierce: Study: mutations in Russian #TB strain make it drug-resistant. Story via Wired UK | Follow @EmilyMFierce

> Tsunami of biotech IPOs will test investors' appetite for R&D. Article

> A top Pfizer drug flops in two PhIII lung cancer studies. Piece

Pharma News

@FiercePharma: Merck KGaA CFO jumps ship amid turnaround he helped engineer; shares slide. Story | Follow @FiercePharma

@TracyStaton: Q4 sales up, 2013 down, esp in US: Bristol-Myers Squibb Reports 4th Quarter and Full Year 2013 Results. Release | Follow @TracyStaton

@EricPFierce: Ranbaxy will need new markets as FDA closes window on U.S., analysts predict. Piece | Follow @EricPFierce

@CarlyHFierce: Bristol-Myers impresses with trimmed-down costs, pumped-up sales. Story | Follow @CarlyHFierce

> Merck KGaA CFO jumps ship amid turnaround he helped engineer; shares slide. Story

> Spurred by pricey Gilead hep C drug, payers cook up new cost-control moves. Article

> Pfizer weighs legal options as PA Supreme Court revives Redux design-defect suit. News

> Ranbaxy will need new markets as FDA closes window on U.S., analysts predict. More

CRO News

> Report: Indian clinical trials fell 93% last year. Story

> CRO Genae reaches into Germany for device trials. News

> ResearchDx pushes into the Middle East for diagnostics development. Article

> Catalent lines up for an IPO worth $100M--or much more. More

> Covance adding 500 jobs in U.K. nutrition expansion. Piece

> Datatrak, Clinverse team up for clinical trial tech. Item

Biotech IT News

> The clinical trial technology sector could top $5B by 2018, report says. Story

> Sony teams with Illumina to crack the Japanese genome market. More

> Report: Pharma is missing a Big Data opportunity by ignoring social media. News

> The NCI is offering $20M to pilot projects that move cancer genomics into the cloud. Piece

> U.K. to digitize patient health records and sell access to biopharma researchers. Article

> Novo Nordisk taps Trialbee for online recruitment of trial patients. Item

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CMR Surgical will have a new CEO at the top of the year, as it kicks off the global launch of its modular Versius system while awaiting FDA approval.

The ADDF announced its second round of research awards, with a total of $6 million in new funding for diagnostic tests.