CRO: adaptive trial design could help address renal denervation challenges; Dubai to develop cutting-edge medical Dx center;

@FierceMedDev: How to gain new stent sales in a sluggish market: bulk discount deals. Story | Follow @FierceMedDev

@MarkHFierce: For Covidien, a ventilation system wins a CE mark after other product setbacks in the space. More | Follow @MarkHFierce

@MichaelGFierce: New manufacturing technique offers tailored delivery nanoparticles made of iron, silver and silicon. Article from FierceDrugDelivery | Follow @MichaelGFierce

@EmilyWFierce: White noise sleep machines at full volume could cause hearing damage in infants, say researchers. News | Follow @EmilyWFierce

> In light of Medtronic's ($MDT) renal denervation trial setback, CRO Aptiv Solutions said an adaptive trial design could help startups developing their own technology in the space to hedge their bets. Story

> GC Aesthetics raised $60 million in new funding to help expand its breast implant business, attracting investment from new investor OrbiMed, plus existing VCs Montreaux Equity Partners and Oyster Capital. Story

> Dubai will develop a state-of-the-art medical diagnostic center with plans to link it to 5,000 similar facilities around the world. Story

> 3-D printing is increasingly being used in medical device manufacturing, and a new study predicts the sector will grow close to 23% in 2014, hitting $1.4 billion. Story

> Hologic ($HOLX) said it will be showcasing its breast-related diagnostic, medical imaging and surgical products at the European Society of Radiology annual meeting in Vienna, Austria, from March 6-10, 2014. Item

Biotech News

@FierceBiotech: GlaxoSmithKline hits the brakes on an anti-inflammatory drug from Galapagos. News | Follow @FierceBiotech

@JohnCFierce: Remember that big Gilead bet on Pharmasset? It paid off and made John Martin a billionaire. Item | Follow @JohnCFierce

@DamianFierce: India's Lupin queues up for a share of the biosimilar boom. Story | Follow @DamianFierce

@EmilyMFierce: Experimental supplement extends lifespan, stops metabolic disease in mice. Article from FierceBiotechResearch | Follow @EmilyMFierce

> Roche racks up another PhIII setback as MetMab flops against lung cancer. News

> Scientific insights into brain chemistry trigger drug trials for Down syndrome. Story

> Investigators ID a rare antibody that may offer a key to elusive HIV vaccine. Research

Pharma News

@FiercePharma: Best-read over the weekend: Pradaxa, Xarelto makers dispute purported Eliquis safety edge. Piece | Follow @FiercePharma

@TracyStaton: The graph's the thing: Takeda admits to 'inappropriate' drug advertising in Japan. News (sub. req.) | Follow @TracyStaton

@EricPFierce: WSJ says Pfizer angling for OTC Lipitor. That will get generic drugmakers' notice. Story | Follow @EricPFierce

@CarlyHFierce: Teva's new Copaxone formula could be a hard sell with payersArticle | Follow @CarlyHFierce

> Questcor, short sellers trade attacks. More

> No merger talk here: Novartis just wants to be friends with Roche, chairman says. Story

> Generic makers to FDA: Labeling rule risky for patients, adds $4B in annual costs. News

CRO News

> InVentiv amps up its biosimilar efforts with latest deal. Story

> Report: VC giant Sequoia unloading $50M stake in India's GVK. News

> Quintiles touts its talent as cash rolls in. Article

> Cardialysis taps AG Mednet to handle an ocean of trial data. Story

> MPI's imaging team-up snags a cyclotron as it preps for opening day. Story

> Charles River looks to Exostar for cloud-based data platform. Brief

Biotech IT News

> Google joins genomics alliance as it prepares industry-focused cloud services. News

> Novartis' pitch to join trial data sharing bandwagon gets frosty reception. Story

> U.K. begins trying to rebuild trust in patient database after months of 'confusion, suspicion and anxiety.' Article

> FDA defends itself against accusations its email snooping broke whistleblower laws. Story

> George Washington University to trial 40-Gbps genomics data transfers with NIH. Article

> NIH adds genetic data from Kaiser, UCSF to online resource. Brief

Suggested Articles

They say you are what you eat, but scientists at Rice University and the University of Washington may be taking that maxim a step further.

Acutus secured $170 million after acquiring a catheter developer and announcing a slew of new partnerships in arrhythmia treatment and monitoring.

Tangen Biosciences, developers of cheap and portable molecular diagnostics for outside the lab, has raised $9 million to kick off its VC efforts.