CRO: adaptive trial design could help address renal denervation challenges; Dubai to develop cutting-edge medical Dx center;

@FierceMedDev: How to gain new stent sales in a sluggish market: bulk discount deals. Story | Follow @FierceMedDev

@MarkHFierce: For Covidien, a ventilation system wins a CE mark after other product setbacks in the space. More | Follow @MarkHFierce

@MichaelGFierce: New manufacturing technique offers tailored delivery nanoparticles made of iron, silver and silicon. Article from FierceDrugDelivery | Follow @MichaelGFierce

@EmilyWFierce: White noise sleep machines at full volume could cause hearing damage in infants, say researchers. News | Follow @EmilyWFierce

> In light of Medtronic's ($MDT) renal denervation trial setback, CRO Aptiv Solutions said an adaptive trial design could help startups developing their own technology in the space to hedge their bets. Story

> GC Aesthetics raised $60 million in new funding to help expand its breast implant business, attracting investment from new investor OrbiMed, plus existing VCs Montreaux Equity Partners and Oyster Capital. Story

> Dubai will develop a state-of-the-art medical diagnostic center with plans to link it to 5,000 similar facilities around the world. Story

> 3-D printing is increasingly being used in medical device manufacturing, and a new study predicts the sector will grow close to 23% in 2014, hitting $1.4 billion. Story

> Hologic ($HOLX) said it will be showcasing its breast-related diagnostic, medical imaging and surgical products at the European Society of Radiology annual meeting in Vienna, Austria, from March 6-10, 2014. Item

Biotech News

@FierceBiotech: GlaxoSmithKline hits the brakes on an anti-inflammatory drug from Galapagos. News | Follow @FierceBiotech

@JohnCFierce: Remember that big Gilead bet on Pharmasset? It paid off and made John Martin a billionaire. Item | Follow @JohnCFierce

@DamianFierce: India's Lupin queues up for a share of the biosimilar boom. Story | Follow @DamianFierce

@EmilyMFierce: Experimental supplement extends lifespan, stops metabolic disease in mice. Article from FierceBiotechResearch | Follow @EmilyMFierce

> Roche racks up another PhIII setback as MetMab flops against lung cancer. News

> Scientific insights into brain chemistry trigger drug trials for Down syndrome. Story

> Investigators ID a rare antibody that may offer a key to elusive HIV vaccine. Research

Pharma News

@FiercePharma: Best-read over the weekend: Pradaxa, Xarelto makers dispute purported Eliquis safety edge. Piece | Follow @FiercePharma

@TracyStaton: The graph's the thing: Takeda admits to 'inappropriate' drug advertising in Japan. News (sub. req.) | Follow @TracyStaton

@EricPFierce: WSJ says Pfizer angling for OTC Lipitor. That will get generic drugmakers' notice. Story | Follow @EricPFierce

@CarlyHFierce: Teva's new Copaxone formula could be a hard sell with payersArticle | Follow @CarlyHFierce

> Questcor, short sellers trade attacks. More

> No merger talk here: Novartis just wants to be friends with Roche, chairman says. Story

> Generic makers to FDA: Labeling rule risky for patients, adds $4B in annual costs. News

CRO News

> InVentiv amps up its biosimilar efforts with latest deal. Story

> Report: VC giant Sequoia unloading $50M stake in India's GVK. News

> Quintiles touts its talent as cash rolls in. Article

> Cardialysis taps AG Mednet to handle an ocean of trial data. Story

> MPI's imaging team-up snags a cyclotron as it preps for opening day. Story

> Charles River looks to Exostar for cloud-based data platform. Brief

Biotech IT News

> Google joins genomics alliance as it prepares industry-focused cloud services. News

> Novartis' pitch to join trial data sharing bandwagon gets frosty reception. Story

> U.K. begins trying to rebuild trust in patient database after months of 'confusion, suspicion and anxiety.' Article

> FDA defends itself against accusations its email snooping broke whistleblower laws. Story

> George Washington University to trial 40-Gbps genomics data transfers with NIH. Article

> NIH adds genetic data from Kaiser, UCSF to online resource. Brief