Cook notches first U.S. Zilver PTX implant; Allergan closes $350M SkinMedica buy;

 @FierceMedDev: Nanotech transforms blood tumor cells into viable Dx tool. News | Follow @FierceMedDev

@MarkHFierce: Smith & Newphew vs. ConvaTec over a wound dressing patent issue; ConvaTec won. Report | Follow @MarkHFierce

 @DamianFierce: Privately held CardiacAssist is targeting the heart pump market after getting FDA OK for a pivotal trial. Story | Follow @DamianFierce

> Riverside Methodist Hospital in Columbus, OH, treated the first patient with Cook Medical's new Zilver PTX drug-eluting peripheral stent, following its U.S. Commercial launch. Release

> Allergan ($AGN) has wrapped up its $350 million acquisition of SkinMedica, bolstering its aesthetics business. Item

> Smith & Nephew ($SNN) is extending its Legion knee-replacement system with narrower components designed to help surgeons more closely tailor implants to a patient's natural anatomy. More

> Parallax Diagnostics has completed its merger with Endeavor Holdings, bringing along its FDA-approved Target System VT1000 benchtop assay unit. News

> The global medical devices outsourcing market should rise from $21.1 billion in 2012 to $40.8 billion in 2018, a new market report concludes, as demand increases for outsourced product design, regulatory consulting, testing and validation. Item

> Mass Device surveyed its readers and found, unsurprisingly, that people in the industry are pessimistic that the medical device tax will get repealed. Story

Biotech News

 @FierceBiotech: Oncothyreon routed after Merck KGaA's Stimuvax flops in big PhIII lung cancer trial. Story | Follow @FierceBiotech

@JohnCFierce: Ex-GSK scientists grab $18M, neurosciences portfolio for startup. News | Follow @JohnCFierce

@RyanMFierce: Bristol-Myers' Sigal outshines pharma rivals in R&D chief ranking. (Does Jeremy Levin deserve some credit?) More | Follow @RyanMFierce

> Can Big Pharma sustain a swelling rate of new drug approvals? Article

> Regado backers provide $51M to fuel high-stakes PhIII anticoagulant study. News

> Allon shares collapse as ambitious CNS study ends in disastrous flop. Report

Pharma News

@FiercePharma: Lagging Lundbeck cuts its financial outlook for 2013 + 2014, on European sluggishness, R&D costs. More | Follow @FiercePharma

> Actavis CEO's next act may be a Stada buyout. Article

> Pfizer targets 600 primary-care sales jobs. News

Drug Delivery News

> Helix and Merck terminate topical interferon collaboration. Article

> Langer nanoparticle startup Blend bags $16M funding and new CEO. News

> Unigene's oral bone drug doesn't give women the needle. Story

> Drugs sneak through the skin without patches. Item

Biomarkers News

> Myriad to peruse Sanofi insulin trial samples for biomarker clues. Report

> Merck turns to GE agent to track potential Alzheimer's biomarker. Article

> MIT's nanoparticles make cancer biomarkers more visible. News

> Protein doubles as diagnostic and drug target for blood cancer. Story

> SynapDx snags $6M for autism Dx study. Item