Scientists have identified biomarkers that can predict macrosomia, a condition that describes infants with excessively high birth weights. First trimester levels of the placental protein biomarkers PAPP-A, ADAM12, PP13, and PIGF in women with pregestational Type-1 and Type-2 diabetes can indicate high birth-weight babies, researchers say. "Diabetes-induced metabolic disorders are thought to interfere with embryonic organogenesis and early placentation and hyperglycemia is thought to trigger excessive fetal growth," said Dutch researcher Sylwia Kuc in a release. More here