Joyce O'Shaughnessy, a researcher at Baylor Sammons Cancer Center in Dallas, is interviewed by OncLive about the future of breast cancer biomarkers. O'Shaughnessy says that because of the complex "systems biology" nature of breast cancer, it might not be possible to know "every operative pathway and microenvironment." But biomarkers can help with a basic understanding of the biology. She encourages discovery of biomarkers that exclude some patients from studies if they indicate they will not be responsive. O'Shaughnessy also says the focus should not be on so many narrow subsets of patients, but breast cancer biomarkers should apply to a broader range of patients. Story and video