Nano, in vivo 3D gains for imaging

Fluorescence imaging got a boost last week on two separate fronts: at the nano-biotech level via software support for high-end cameras, and in in vivo 3D image acquisition and analysis for disease study.

Andor Technology's imaging EMCCD (electron multiplying charge-coupled device) cameras now boast compatibility with JPK Instruments' software for nano-biotechnology. According to an announcement, the pairing yields integration between fluorescence imaging on the one hand and JPK's NanoWizard atomic force microscopy (AFM) imaging or NanoTracker optical tweezers on the other. Users of JPK's DirectOverlay functionality are now able to use the images coming from their Andor EMCCD cameras.

Separately, Caliper Life Sciences (CALP) has released Living Image 4.0 software for the IVIS in vivo imaging systems. Version 4.0 features spectral unmixing tools to enhance fluorescent sensitivity and automated 3D image acquisition and analysis, providing an anatomical view of disease activity and drug efficacy.

The software aids scientists in visualizing and tracking diseases quantitatively, in small living animals via detection of fluorescent and bioluminescent reporters and functional markers. The 3D images generated with Living Image 4.0 can also be co-registered with CT or MRI results to provide an anatomical context for optical molecular signals, according to an announcement.

- see the Andor announcement
- here's the Caliper release

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