ThromboGenics enters into commercialization agreement for Ocriplasmin with Alcon outside the United States

Leuven, Belgium  -- 16 March, 2012  - ThromboGenics NV (Euronext Brussels: THR), a biopharmaceutical company focused on developing innovative ophthalmic medicines, announces today that it has entered into an agreement with Alcon (a division of Novartis), the global leader in eye care, for the commercialization of ocriplasmin in all markets outside the U.S.  As a result of this important strategic deal, ThromboGenics will  concentrate  on commercializing ocriplasmin in the U.S. where it plans to build its commercial and medical organization to support the product's anticipated launch within the next 12 months.

Under the terms of the  agreement  with  Alcon, ThromboGenics will receive an up-front payment of €75 million. The Company  is also entitled to a further €90 million in  potential near-term milestone payments. Additional milestones bring the  potential  total of up-fronts and milestones to €375 million.

In addition, ThromboGenics will receive royalties on net sales of ocriplasmin that are commensurate with a product that has successfully completed Phase III development and that has been filed for regulatory approval.Under the agreement ThromboGenics will have a strategic and focused operational role in the commercialization of ocriplasmin in the five largest European markets, enabling it to build the foundation for an expanding ophthalmology franchise.

In addition to the commercial introduction of ocriplasmin  in markets outside the U.S.,  the agreement specifies that Alcon and ThromboGenics will work together, and share the costs, to further develop new clinical applications of the product that the companies will introduce in their respective territories.

ThromboGenics has completed an  extensive clinical development program, including two successful Phase III studies that have shown that ocriplasmin could play an important role in treating symptomatic VMA including macular hole.  Symptomatic VMA is an increasingly recognized sight-threatening disease of the vitreoretinal interface.  VMA may lead to symptoms such as distorted vision, decreased visual acuity and central visual field defects.  

VMA can cause traction resulting in anatomical damage including formation of a macular hole, which may lead to severe visual consequences and central blindness.

Members of the international retina community have already  shown great interest in ocriplasmin, as it could for the first time provide them with a pharmacological option to treat patients with symptomatic VMA including macular hole. The availability of ocriplasmin may also enable retina specialists to treat patients earlier than they do with surgery. This could address a significant unmet need as earlier intervention  has been shown to  limit the progress of the disease and its related complications.

ThromboGenics is confident that  ocriplasmin  has  significant  commercial potential, given estimates that more than 300,000 patients in Europe alone could potentially benefit from this novel treatment.

Dr Patrik De Haes, CEO of ThromboGenics, commented, "Today's collaborative deal with Alcon, the global leader in eye  care, to commercialize ocriplasmin  outside of the United States is a major milestone for ThromboGenics. We are pleased that Alcon has recognized the potential of ocriplasmin to change the way symptomatic VMA including macular hole is treated. Alcon is the ideal partner for an innovative retinal therapy given its  global sales, marketing and medical capabilities in the ophthalmic market and its commitment to making ocriplasmin a success. We are now concentrating on bringing ocriplasmin to the U.S. market ourselves and are building the commercial and medical organization needed to support the product's anticipated launch. I have no doubt that today's deal will generate significant value for ThromboGenics' shareholders, and I am looking forward to working with Alcon to ensure that ocriplasmin can reach the  thousands of  patients globally who could benefit from  this innovative  pharmacological treatment."

Kevin Buehler, Division Head of Alcon said, "There are thousands of symptomatic vitreomacular adhesion patients  who currently do not have an available  treatment option. The clinical  results for ocriplasmin show  improved visual function and that earlier intervention may limit the progression of the disease," said Kevin Buehler, Division Head for Alcon. "Ocriplasmin is a strategic fit for  Alcon and is expected to further enhance our portfolio of innovative treatments for the eye."

 

About ThromboGenics
ThromboGenics is a biopharmaceutical company focused on developing  and commercializing  innovative ophthalmic medicines. The Company's lead product, ocriplasmin, has successfully completed two Phase III clinical trials for the pharmacological treatment of symptomatic vitreomacular adhesion (VMA). The MAA for ocriplasmin has been accepted for review in Europe and the BLA will be re-submitted in the U.S. by April 2012. Ocriplasmin is in Phase II clinical development for additional vitreoretinal conditions. ThromboGenics is also developing novel antibody therapeutics in collaboration with BioInvent International. These include TB-402 (anti-Factor VIII), a long-acting anticoagulant in Phase II, and TB-403 (anti-PlGF), in Phase Ib/II for cancer in partnership with Roche. ThromboGenics is headquartered in Leuven, Belgium. The Company is listed on the NYSE Euronext Brussels exchange under the symbol THR. More information  is available at 
www.thrombogenics.com.

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