Add Boehringer Ingelheim to HitGen’s drug discovery collaboration list

handshake
HitGen has formed a drug discovery research collaboration with Boehringer Ingelheim to identify novel small-molecule leads.

Boehringer Ingelheim is joining a long list of biopharma companies and research institutes lining up for HitGen’s drug discovery capabilities centered around DNA-encoded library (DEL).

Like its previous collaborations, Chengdu, China-based HitGen did not disclose specific therapeutic areas of interest or financial details, but said it will receive upfront payments and be eligible for milestone payments.

During the synthesis process, HitGen adds building blocks to novel chemical structures through a technique called “Split & Pool,” then encodes each compound with a known sequence of DNA. The company said on its website that it has produced over 800 DELs with all together 85 billion DNA-encoded compounds.

Webinar

How ICON, Lotus, and Bioforum are Improving Study Efficiency with a Modern EDC

CROs are often at the forefront of adopting new technologies to make clinical trials more efficient. Hear how ICON, Lotus Clinical Research, and Bioforum are speeding database builds and automating reporting tasks for data management.

RELATED: China’s HitGen bags new drug discovery deal with Aduro

The compounds are screened simultaneously against a target, and only those with strong affinity to the protein will be advanced into the next phase, where the structures of selected chemicals will be identified via DNA sequencing.

With that technology, HitGen has formed many drug discovery partnerships with the industry and academics. In 2017 alone, before the BI deal, it entered into research collaborations with Takeda, Aduro, Leo Pharma, the Scripps Research Institute, Pfizer, Merck & Co. and Cancer Research U.K.

HitGen currently has more than 20 projects in research, with two in preclinical candidate compound generation and one in lead generation. It offers different partnering models, can design and synthesize DELs on specific requests, screen its DELs against targets provided by a partner and work with partners to co-develop lead candidates or out-license projects.

Suggested Articles

Horizon Therapeutics is expanding its U.S. footprint to the Bay Area—the company unveiled a new R&D and manufacturing site in South San Francisco.

Azeria Therapeutics has raised £32 million ($41 million) to take its estrogen receptor positive breast cancer program into the clinic.

Biogen’s Al Sandrock has given a bullish assessment of Alzheimer’s disease drug aducanumab. The head of R&D at Biogen thinks the drug works, despite i