Swiss bio Addex halts Parkinson's test as trial delays tick up on COVID-19 disruption

Switzerland
Swiss biotech Addex Therapeutics made the decision to halt a trial of its Parkinson's disease candidate as COVID-19 starts to spread more rapidly in the country. (Getty Images)

Addex Therapeutics has seen its shares down 15% on the news that it has had to delay a registrational study of its Parkinson’s disease candidate.

The trial, known as study 301, was of dipraglurant to treat levodopa-induced dyskinesia associated with Parkinson’s disease (PD-LID). The company says it has “been postponed” with no timelines in place for its restart because of the continued spread of COVID-19 in Europe and the U.S. (where the trials are being conducted).  

It’s also pushing back its financials and conference call until April 8. This comes as its native Switzerland has seen cases shoot past 1,000 over the past few days, with the country closing schools and banning large crowds in an effort to stop the spread, which has widened dramatically over the past week.

Sponsored by BHE

[Webinar] State of Data Analytics and Machine Learning in the Life Sciences Industry: 2020 Benchmarking Survey

Thursday, June 25, 2020 | 2:00pm ET | 11:00am PT

Join us Thursday, June 25th for a look at the current state of analytics in the life sciences industry. We will present the results from our industry survey with FiercePharma on how 100 of your peers are leveraging data analytics to respond to today’s challenges and generate timely, high value insights.

Given that many of the patients for this trial are in a high-risk group for COVID-19, the biotech said it was simply the only choice to make given new government guidance.

“Sites are temporarily suspending on-site visits for monitors, vendors, and all other non-patient visitors and several sites have cancelled all non-essential patient visits,” said Roger Mills, M.D., chief medical officer of Addex.

“Priority is now rightly being placed on how to manage regular care for patients in the light of the increasing COVID-19 containment requirements. We care about the well-being of all PD patients and do not wish to have them make the additional visits to doctors’ offices that are required in a clinical study, putting them at increased risk of contracting COVID-19.”

Addex is conducting its trials with a CRO and said it will now work with it “to continue preparations to start the study as soon as it is appropriate to do so.”

This comes a day after Provention Bio said it was delaying a phase 3 trial in diabetes “out of an abundance of caution to protect patients, caregivers, clinical site staff, company employees and contractors.”

Suggested Articles

Singapore is planning to outfit each of its 5.7 million residents with a simple wearable device to track people who have been exposed to COVID-19.

The agency delivered its first batch of antibody test results in May, covering a dozen products independently evaluated by the NIH and CDC.

After delivering a "positive surprise" in December, Biogen is painting a fuller picture of its lupus drug.