Prexton Therapeutics raises €8.7 million ($10 million) in a Series A round

Geneva, Switzerland, February 24 2015 - Prexton Therapeutics, a biopharmaceutical company developing novel therapeutic compounds for the treatment of CNS conditions including Parkinson's disease, today announces the closing of a Series A financing of €8.7 million ($10 million) co-led by Sunstone Capital and Ysios Capital. MS Ventures, the company's founding investor, will also participate.

Prexton Therapeutics was founded in 2012 by Francois Conquet and MS Ventures as part of the Merck Serono Entrepreneur Partnership Program, a facility set-up to support the creation of spin-offs from Merck Serono.

This first funding will help Prexton Therapeutics to develop novel small molecules that target the metabotropic Glutamate Receptor 4 (mGluR4) up to completion of Phase 1. This has the potential to improve motor complications in Parkinson's disease patients. The compounds were originally licensed from Domain Therapeutics, a French biopharmaceutical R&D company specializing in G protein-coupled receptors (GPCRs).

"Our lead compound has demonstrated impressive results in animal models. We look forward to advancing this compound up to the clinical stage in the coming year," said Francois Conquet, CEO of Prexton Therapeutics.

The Prexton team combines the best research and development expertise in the CNS field. They have collaborated together for many years and each member has a successful background in the pharma industry. "The caliber of the team and their collective scientific and industry expertise will make a huge impact in the development of this new series of molecules for Parkinson's disease," said Andreas Segerros, Partner at Sunstone Capital.

"Prexton Therapeutics is taking a uniquely promising approach to address Parkinson's disease; a neurodegenerative pathology which still has huge unmet medical needs," said Raúl Martín-Ruiz, Investment Director at Ysios Capital.

"Prexton is taking a unique and novel approach to develop treatments for Parkinson's disease by stimulating a compensatory system that is not impacted by the disease. MS Ventures has been supporting Prexton from its foundation and we are excited about the progress the program has made so far and that we are about to reach clinical stage this year," said Jasper Bos, Senior Director at MS Ventures.

In the course of this fundraising, Andreas Segerros of Sunstone and Raúl Martín-Ruiz of Ysios, will join the Board of Directors of Prexton. Jasper Bos will continue to represent MS Ventures.

About Parkinson's disease

Parkinson's disease is a chronic and progressive neurological disorder characterized by a number of symptoms including tremors, limb stiffness, slowness of movements and difficulties with posture and balance. It is estimated that more than one million people in the United States live with the disease. Parkinson's disease is more prevalent in people over 60. The incidence of the disease is expected to increase as the average age of the population increases. Today, the worldwide market of Parkinson's disease is around $3bn and is dominated by matured Dopaminergic treatments, which frequently induce negative side effects. There is an overall consensus in the field supporting the development of more efficient approaches, while limiting and even abolishing the occurrence of adverse effects.

About Prexton Therapeutics

Prexton Therapeutics is a Swiss-based biopharmaceutical company, founded in 2012 by Francois Conquet and MS Ventures as part of the Merck Serono Entrepreneur Partnership Program, a facility to support the creation of spin-offs from Merck Serono. Prexton Therapeutics applies a new scientific approach that fully integrates molecular, behavioral and chemistry technologies to address Parkinson's disease and other brain disorders. Prexton Therapeutics uses its powerful discovery platform to target specific novel compounds focused on the treatment of Parkinson's disease.

About Sunstone Capital

Sunstone Capital is a leading pan-European venture capital investor founded in 2007 by an international team of industry experts with combined entrepreneurial, operational and financial experience. Sunstone Capital focuses on developing and expanding early-stage life science and technology companies with strong potential to achieve global success. Within life science, Sunstone Capital has invested in more than 50 companies in the areas of pharmaceuticals, medical technologies and diagnostics. It has completed several successful M&A transactions and IPOs. With total funds of €700 million under management, Sunstone Capital is one of the larger European venture capital investors.

About Ysios Capital

Ysios Capital is a leading Spanish independent venture capital firm that provides private equity financing to early- and mid-stage human healthcare and life science companies. It targets the entire healthcare and biotechnology industry with a special focus on pharmaceuticals, diagnostics and medical devices. Founded in 2008, Ysios Capital has € 118 million in assets under management, distributed over two funds. The second fund has a target size of €100 million. It will remain open to new investors until September 2015.

About MS Ventures

MS Ventures is the strategic, corporate venture arm of the biopharmaceutical division of Merck KGaA, Darmstadt, Germany. It invests globally in emerging biotechnology companies that develop products and or technologies that have the potential to significantly improve patient outcomes. Along with the €100 million MS Ventures fund, our team also manages the €30 million Entrepreneur Partnership Program fund, established to support the creation of spin-offs, and the €10 million Israel Bioincubator Fund, focused on pre-seed and seed opportunities initiated in Israel.

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