MedImmune and Abpro launch bispecific antibody spinout

AstraZeneca's biologics arm will help nurture spinoff AbMed in its early stages.

AstraZeneca’s biologics arm MedImmune and synthetic biology co Abpro have joined forces on a new Ang2-VEGF research collab that will come together under a new spinout.

The spinout, dubbed AbMed, will work on a preclinical, bispecific antibody targeting angiopoietin-2 and vascular endothelial growth factor (Ang2-VEGF), with Abpro helping it run day-to-day ops.

“Several potential therapeutic areas will be explored” where blocking the Ang2 and VEGF pathways with the bispecific antibody “may provide clinical benefit,” the companies said in a statement, although further detailed targets were not shared, except that it “may be useful in targeting disease indications with high unmet needs.”

Virtual Roundtable

ESMO Post Show: Highlights From the Virtual Conference

Cancer experts and pharma execs will break down the headline-making data from ESMO, sharing their insights and analysis around the conference’s most closely watched studies. This discussion will examine how groundbreaking research unveiled over the weekend will change clinical practice and prime drugs for key new indications, and panelists will fill you in on the need-to-know takeaways from oncology’s hottest fields.

AbMed will officially work as a subsidiary of Abpro, which is also set to take the lion’s share of global development and commercialization rights to the program, while MedImmune will gain future biobucks, as well as hold a minority equity stake in AbMed.

"This agreement arises out of MedImmune's culture of entrepreneurship and innovation—both in science and in business," said Jane Osbourn, VP of R&D at MedImmune. "We believe partners like Abpro can help us maximize our extensive preclinical portfolio to advance therapies for patients."

This comes after the beginning of some staff cuts from MedImmune over the summer as it looks toward a deeper focus (and a larger cash pile) for its oncology research.

Suggested Articles

Novartis is forging ahead with the development of spartalizumab in "many, many other indications" despite the setback.

Chi-Med has detailed plans to seek approval from the FDA later this year in part on the strength of data from Chinese phase 3 trial.

Takeda tapped Roche’s Foundation Medicine to develop tissue- and blood-based companion diagnostic tests for its portfolio of lung cancer therapies.