Immunology Data on PV-10 to Be Presented at the American Association for Cancer Research Annual Meeting

-- Moffitt Cancer Center Poster Presentation on April 8, 2013 --

Immunology Data on PV-10 to Be Presented at the American Association for Cancer Research Annual Meeting

<0> Provectus Pharmaceuticals, Inc.Peter R. Culpepper, CFO, COO866-594-5999 #30orPorter, LeVay & Rose, Inc.Marlon Nurse, DM, SVP – Investor RelationsBill Gordon, SVP – Media Relations212-564-4700 </0>

Provectus Pharmaceuticals, Inc. (OTCQB: PVCT, ), a development-stage oncology and dermatology biopharmaceutical company, announces that mechanism data on the induction of tumor specific immunity after intralesional PV-10 treatment will be presented by researchers from Moffitt Cancer Center and the University of South Florida in a poster presentation at the American Association for Cancer Research Annual Meeting in Washington, DC.

The poster, based upon abstract #1248 entitled "Intralesional Injection with PV-10 Induces a Systemic Anti-tumor Immune Response in Murine Models of Breast Cancer and Melanoma," authored by Shari A. Pilon-Thomas, Amy Weber, Krithika Kodumudi, Lisa Kuhn, Paul Toomey, Amod Sarnaik, will be presented on April 8, 2013, from 1:00 p.m. - 5:00 p.m. in Hall A-C, Poster Section 5, Poster #28.

Craig Dees, Ph.D., CEO of Provectus Pharmaceuticals said, “The researchers at Moffitt are providing valuable insights into how PV-10 harnesses the immune system in specific response to the injected tumor. Although the study being presented was done in murine models of melanoma and breast cancer, the currently open clinical trial at Moffitt is designed to investigate this mechanism in melanoma patients. We are pleased to enhance our understanding of intralesional PV-10 and its potential to produce a systemic benefit in cancer patients.”

PV-10 is Provectus Pharmaceuticals' novel oncology drug designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing potential for systemic side effects.

The AACR is the oldest and largest scientific organization in the world focused on every aspect of high-quality, innovative cancer research. Its reputation for scientific breadth and excellence attract the premier researchers in the field. The programs and services of the AACR foster the exchange of knowledge and new ideas among scientists dedicated to cancer research, provide training opportunities for the next generation of cancer researchers, and increase public understanding of cancer.

Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its novel oncology drug PV-10 is designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing potential for systemic side effects. Its oncology focus is on melanoma, breast cancer and cancers of the liver. The Company has received orphan drug designations from the FDA for its melanoma and hepatocellular carcinoma indications. Its dermatological drug PH-10 also targets abnormal or diseased cells, with the current focus on psoriasis and atopic dermatitis. Provectus has recently completed Phase 2 trials of PV-10 as a therapy for metastatic melanoma, and of PH-10 as a topical treatment for atopic dermatitis and psoriasis. Information about these and the Company's other clinical trials can be found at the NIH registry, . For additional information about Provectus please visit the Company's website at or contact Porter, LeVay & Rose, Inc.

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