Genmab Announces RG1507 Update

Genmab Announces RG1507 Update

Copenhagen, Denmark; December 4, 2009 - Genmab A/S (OMX: GEN) announced today that Roche has informed Genmab that it will discontinue development of RG1507, a monoclonal antibody directed against the insulin-like growth factor-1 receptor (IGF-1R). The decision was due to the available clinical data, the large number of molecules targeting the same pathway that are presently in development and the prioritization of the Roche portfolio. The decision was not as a result of safety concerns.


RG1507 is a fully human antibody created by Genmab under its collaboration with Roche. RG1507 was in Phase II development for multiple indications including sarcoma and non small cell lung cancer.


"Despite this setback, Roche and Genmab continue to have a strong working relationship, with one shared aim of developing and providing novel efficacious agents to the patients that need them," said Lisa N. Drakeman, Ph.D., Chief Executive Officer of Genmab.

Suggested Articles

Pliant Therapeutics will use the proceeds to push its lead program through midstage trials in fibrotic liver and lung diseases.

Cancer biotech Novellus has struck a deal with Plexxikon for its early- to midstage BRAF-inhibiting hopeful PLX8394.

Chinook Therapeutics is set to merge with fallen Big Pharma darling Aduro Biotech to create a kidney disease player with $180 million in cash.