A small Phase II trial of Corgentech's 4975 for hernia pain failed to demonstrate a difference between the drug and a placebo. Patients either received a mix of paracetamol and ibuprofen along with either the experimental drug or a placebo. Researchers blamed the mix of pain drugs for all patients as a reason for the flat response rate.
"We believe that concomitant administration of pain killing drugs may have confounded the results of this trial since the results are inconsistent with data obtained from multiple previous Phase II trials of 4975 that demonstrated significant, sustained pain reduction versus placebo in other indications," said Daniel Gennevois, vice president of medical affairs at Corgentech.
- here's the UPI report