Charles River inks $585M buyout; Roche leads $175M Flatiron round;

@FierceBiotech: The scoop on every new drug approved in 2015. Feature | Follow @FierceBiotech

@JohnCFierce: It's all happening so fast--Alector raises $29M; NextCure launches with $67M; Pfizer leads $15M round for Cortexyme. More | Follow @JohnCFierce

@DamianFierce: Tweeting from HATEFUL 8 intermission & have to say it was jarring when Bruce Dern turned to the camera and said "The 8 of us sure are h8ful." | Follow @DamianFierce

> Charles River Laboratories ($CRL) extended its run of acquisitions with a $585 million buyout of WIL Research, picking up a company the CRO said will expand its global footprint and bolster its manufacturing capabilities. Story

> Flatiron Health has raised $175 million for its cloud-based oncology platform, with Roche ($RHHBY) taking the lead. Release

Medical Device News

@FierceMedDev: KKR, Panasonic form newco Ascensia from Bayer Diabetes buy for $1.1B. Article | Follow @FierceMedDev

@EmilyWFierce: Drug price increases saw 'high water mark' year in 2015: Analysts. FiercePharma story | Follow @EmilyWFierce

@VarunSaxena2: NEA partner outlines challenging med tech VC landscape heading into 2016. Article | Follow @VarunSaxena2

> As NEA buys in, FDA calls for more innovative, affordable and effective hearing aids. Story

> J&J launches consumer health and wellness tech accelerator. Article

> Stealth machine learning startup raises $10M to develop a heart disease detection algorithm. More

Pharma News

@FiercePharma: China's Jiangsu Hansoh plans $3B IPO to tap investor demand. FiercePharmaAsia story | Follow @FiercePharma

@CarlyHFierce: MannKind resolves to find new Afrezza marketing deal after Sanofi bails on partnership. FiercePharmaMarketing story | Follow @CarlyHFierce

> If hospitalized Valeant chief makes an exit, it'll be without a parachute. Article

> Drug price increases saw 'high water mark' year in 2015: Analysts. Report

CRO News

> PPD spins out its in-house biotech as sale rumors swirl. More

> Charles River spends $585M on WIL Research amid a buyout spree. Article

> UCB taps Evotec to pitch in on drug discovery. Story

> Altasciences rebrands its web of CROs in hopes of standing out. Report

Pharma Manufacturing News

> Baxter recalls more of its saline solutions after a bug was found. Report

> PharMEDium recalls blood pressure control drug due to discoloration/degradation. More

> French developer TxCell signs Belgian CMO for manufacturing deal. Story

> GSK Australia plant to begin using blow-fill-seal technology for vaccines. Item

> Hospira recalls magnesium sulfate injectable due to bad barcoding. Article

Pharma Asia News

> China's Simcere seeks return to public market with $1B HKEx IPO. Story

> Chinese New Year alert in Hong Kong after bird flu fatality. News

> Wanda plans $2.3B hospital investment in China. More

> Precision medicine plan in China may be announced in March. Report

> Takeda bets on microbiome targets in GI push with Enterome deal. Article

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