Tag:

Zelboraf

Latest Headlines

Latest Headlines

GlaxoSmithKline's melanoma combo beats Roche's Zelboraf in Phase III

GlaxoSmithKline is touting stellar Phase III results for an in-development combo therapy for melanoma, saying its treatment beat out Roche's Zelboraf in overall survival and led independent advisers to recommend an early end for the study.

Rise of personalized drugs means fewer 'dinosaur' trials

Now that targeted therapies like Roche's Zelboraf and Bayer's Stivarga have raced through the FDA and into patients' hands, drug developers are relying less and less on old-fashioned randomized controlled trials.

Yervoy-Zelboraf combo trial stopped on toxicity worries

Hopes for a quick one-two punch against melanoma have hit a snag. A Phase I trial testing Bristol-Myers Squibb's Yervoy and Roche's Zelboraf in melanoma patients was stopped after signs of liver toxicity developed in several patients.

U.K. finally approves Roche's Zelboraf and BMS' Yervoy

Skin cancer drugs from Roche and Bristol-Myers Squibb, which can provide some relief to patients with deadly skin cancers and which have big futures for sales, have finally made it past the U.K. price watchdog NICE. But this only came to pass after both companies offered undisclosed discounts to the National Health Service.

Top U.S. hospital won't use pricey Sanofi cancer drug

Watch out, oncology drugmakers. Memorial Sloan-Kettering Cancer Center has made a move that could crimp your ambitions for premium pricing. The leading hospital says it will exclude Sanofi's ($SNY) new colorectal cancer drug Zaltrap from its treament protocols--because its price is twice as high as competing treatments, but has proven no more effective than its rivals, namely Roche's ($RHHBY) Avastin.

Celgene's Abraxane delivers in melanoma study

Will Abraxane join the new gang of melanoma fighters?

Celgene's Abraxane delivers in melanoma study

Will Abraxane join the new gang of melanoma fighters? The Celgene ($CELG) drug, a reformulated version of the chemo drug paclitaxel, kept the cancer at bay for longer than the standard chemotherapy, dacarbazine, a new study found.

Report: Roche's Zelboraf, BMS' Yervoy control their segment

A new market report says Yervoy from Bristol-Myers Squibb ($BMY) and Zelboraf from Roche ($RHHBY) have sewn up two-thirds of the market for treating advanced malignant melanoma and will underpin significant growth in sales in developed markets for a decade.

U.K. to revamp NICE appeals after industry complaints

The National Institute for Health and Clinical Excellence is overhauling its appeals process. Amid criticism from the industry, including the U.K. trade group ABPI, the cost-effectiveness watchdog will add independent, non-agency members to its appeals panels.Those panels will no longer be chaired by agency types, but by outsiders.

NICE stiff-arms Roche melanoma drug once again

Roche ($RHHBY) tried to sway the U.K.'s cost-effectiveness watchdogs toward its targeted melanoma drug Zelboraf. But it failed. The National Institute for Health and Clinical Excellence stuck to its rejection.