A tussle over the termination of a trial to assess the cardiovascular safety of obesity drug Contrave is in swing, with Orexigen Therapeutics and Takeda Pharmaceutical entering a dispute process, according to Reuters, with earlier data breaches the subject of a separate issue.
An international group of investigators led by a scientist at Cedars-Sinai has identified a genetic mutation that protects people from Type 2 diabetes. And they say it makes for a good target for drug developers.
No drugmaker wants a generic challenger for a product it relies on--and certainly not two generics challengers. But in the case of Vivus, which has sued Actavis and now Teva over patent infringement for weight-loss drug Qsymia, the generic interest could be an "incremental positive," one analyst believes.
Less than a year ago, Arena marketing partner Eisai pledged to add another 200 staffers to its rep army for obesity therapy Belviq, bringing the total force to 600. Now, though, the Japanese pharma is doing some stateside job-trimming, and the restructuring will affect Arena's med, too.
To transport a hunger-suppressing molecule to the gut as a treatment for obesity, researchers at Vanderbilt University have put bacteria to work. The bacteria become lodged in the digestive system and release the lipid for up to a year at a time, altering the gut microbiome to stave off weight-related problems like diabetes and heart disease.
Startup MHB Labs announced the receipt of $1.1 million in seed financing from Romulus Capital and other angel investors in support of its drug delivery technology for convenient administration of a commercially available but little-used medication that could have applications in the men's health space.
The U.S. Food and Drug Administration has placed a hold on enrollment in the ongoing U.S. pivotal trial for the EndoBarrier. The device is a gastric liner from GI Dynamics that is intended to inhibit the absorption of nutrients, thereby providing weight loss and addressing obesity and Type 2 diabetes.
The Mayo Clinic and Gentag are partnering to develop next-generation, wireless, disposable patch sensors to enable researchers to track patient movements in order to better address conditions such as diabetes and obesity.
The FDA isn't happy with Orexigen, which put out some early positive cardio data for obesity drug Contrave Tuesday. The way the FDA sees it, the data were too early, and it's now asking Orexigen for a second outcomes study. But meanwhile, the new stats have changed some analysts' minds about Contrave's safety profile--something that could give it a leg up in a crowded market going forward.
Two different teams at Columbia and Harvard have independently created neurons out of iPS cells that regulate appetite, offering a new model for investigators who are studying new weight drugs and various elements of weight control.