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WHO out to test BioCryst bird flu therapy

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The World Health Organization says it wants to use BioCryst's peramivir to treat patients who have contracted the deadly H5N1 bird flu. Avian flu has a mortality rate in humans of 60 percent, and health officials say that peramivir has demonstrated an ability to achieve therapeutic levels in the blood stream that are 100 times higher than Tamiflu, which is the current drug being used to counter the virus. Birmingham, AL-based BioCryst has recorded positive data for peramivir in animals and recently won a $103 million grant to support additional testing.

- here's the report from the Budapest Business Journal

ALSO: Several poor Asian countries face a dilemma: Replace their dated stockpiles of Tamiflu--which may or may not be effective against bird flu--or gamble that no pandemic occurs. Report

Related Articles:
BioCryst seeks approval for flu trial, signs deal with Roche. Report
BioCryst gets fast-track status for avian flu drug. Report
BioCryst shares peak on hopes for bird flu drug. Report


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The BBJ report states that a level of 400 micrograms/ml is achieved with Tamiflu while 40,000 nanograms/ml is obtained with permavir. If the units are correct, permavir is 10-fold lower than Tamiflu not 100-fold higher!

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