ALSO NOTED: Sheares leaves Merck; Siga touts early-stage smallpox trial; and much more...

> Bradley Sheares, the head of Merck's U.S. drug operations, has left the company. Sheares was once considered a contender for the CEO's job. Adam Schechter is being promoted to replace him. Report

> Siga Technologies announced that its lead smallpox candidate, SIGA-246, successfully demonstrated that it was safe and well tolerated at all dose levels in a Phase I trial. Article

> DeCode Genetics plans to raise $27.8 million through a stock sale. Report

> Roxane Laboratories has recalled a single lot of Azathioprine, a kidney transplant drug, after finding Methotrexate tablets in one bottle. Report

> Schering has decided against exercising an option for one of Predix Pharmaceuticals' imaging agents. Report

> CuraGen and TopoTarget have begun a Phase I/II trial of PXD101 for inoperable hepatocellular cancer. Report

> Nuvo Research has resubmitted its NDA for Pennsaid, a topical non-steroidal anti-inflammatory used for the treatment of osteoarthritis of the knee. Release

And Finally… Researchers say that short-legged people appear to be more prone to diabetes, which may be related to their nutrition or hormones at birth or in childhood. Report