News

Sage up-sizes its ambition on the eve of a much-watched IPO

Biotech luminary Sage Therapeutics is boosting the size of its planned IPO, upping its share offering and expected price range as investors look to its Wall Street debut as a bellwether for the industry.

Virobay banks $8M to accelerate its treatments for pain, autoimmunity

Menlo Park, CA, biotech Virobay tacked another $8 million onto its Series B financing, collecting cash to advance its treatments for neuropathic pain, autoimmune disease and fibrosis.

Alkermes takes its Tecfidera beater into clinical trials for MS

Alkermes has its sights set on Biogen Idec's blockbuster multiple sclerosis treatment, advancing a me-better candidate of its own into Phase I study.

Boehringer's lung drug wins FDA 'breakthrough' tag

Boehringer Ingelheim's treatment for a rare and deadly lung disease picked up the FDA's coveted breakthrough therapy designation, a mark that guarantees a speedy regulatory review and could help the company beat its nearest rival to market.

Concert's spasticity drug gets out from under an FDA hold

The FDA has lifted a partial clinical hold on Concert Pharmaceuticals' treatment for spasticity, allowing the biotech to resume dosing in a Phase I trial.

'Economic patriotism' could dampen biopharma's M&A boom

The fervor over American companies merging with overseas rivals to lower their tax rates has drawn the ire of the Obama Administration, possibly imperiling the so-called inversion deals that have become increasingly popular in biopharma.

Roche is at an Alzheimer's crossroads after mixed data for AC Immune's drug

An Alzheimer's treatment from AC Immune and Genentech posted mixed results in a midstage study, missing its coprimary endpoints but performing well in patients with milder symptoms. That leaves Roche, Genentech's parent company, with a big decision to make on whether to take the plunge into Phase III.

GlaxoSmithKline and Theravance eye Phase III for another COPD contender

The blockbuster duo of GlaxoSmithKline and Theravance are pushing a new respiratory combo therapy into late-stage study, pooling the active ingredients from its last two approved COPD treatments to create a once-daily inhaler.

Cancer vaccine maker immatics adds nearly $30M in Series D

After scooping up an initial €12 million in October and a partnering pact with Roche in November, Germany's immatics has received an additional €22 million ($29.8 million) to wrap up a Series D financing round.

Immunocore and Lilly strike a risk-sharing deal in oncology R&D

Immunocore has struck another cancer R&D pact with one of the world's top drugmakers, signing a deal with Eli Lilly that'll both bring in short-term revenue and help the biotech build value in its proprietary pipeline.

Fed chief spooks biotech investors with bubblish talk

The valuations of small biotech companies are looking a little bloated, according to a Federal Reserve report accompanying testimony by Chairwoman Janet Yellen, an opinion that weighed down share values across the industry.

Three more biotechs target $175M in IPO cash amid market tumult

A new crop of biotech IPO hopefuls has filed to reap a combined $175 million, looking to bankroll efforts in oncology, pain and rare diseases with offerings on an up-and-down market.

La Jolla leaps on NASH fervor thanks to some preclinical success

Successfully treating a mouse is not usually enough to get investors excited, but the promise of an effective drug for nonalcoholic steatohepatitis sent La Jolla Pharmaceuticals' shares up as much as 20% on Tuesday despite very early data.

Why isn't New York City a biotech hub?

New York City is the center of the world's largest economy, home to banner medical institutions and a hotbed of global financiers. But the city has never evolved into the biotech hotbed local leaders have hoped to see, a failure largely due to one of its inescapable traits: high rent.

Novartis plans to test Alzheimer's drugs in patients without symptoms

Learning the lessons of failed trials in mild, moderate and severe Alzheimer's disease, Novartis is planning to study two new treatments on patients who are yet to show any symptoms, hoping to succeed where many others have slipped and delay the onset of the memory-destroying ailment.

Targacept's Alzheimer's hopeful misses the mark in Phase II

Targacept kept the faith in its late-stage Alzheimer's disease drug after ex-partner AstraZeneca walked away from the treatment, but a new mid-stage failure has forced the biotech to pull the plug on TC-1734.

Does crowdfunding work in biotech?

Online fundraising has helped bring movies, comic books and even medical devices to reality, and a new study says the method could be beneficial for drug developers at the earliest of stages.

Merck KGaA brings in a new R&D boss amid its global rethink

Merck KGaA, in the middle of a reformation plot in its biopharma division, has found a new head of drug R&D, moving on after its last research chief lasted just 6 months in the job.

President's advisory group calls for clinical trial changes, incentives for antibiotics R&D

With antibiotic resistance on the rise at a time when Big Pharma has largely left the risk-heavy field, the President's Council of Advisors on Science and Technology is proposing a number of recommendations to lure companies back into the arena and help speed up the development of new antibiotics.

Shire and AbbVie inch closer to a deal after weekend getaway

There's a whiff of inevitability with AbbVie's quest for Shire, as the latter company has confirmed that the two have found an agreeable price, setting the stage for a potential merger worth about $53.7 billion.