News

Booming Gilead gets a blueprint for a big new HQ addition

Gilead has just scooped up an extra 12-acre complex in its home town of Foster City, CA. And the central view comes with room enough for an extra 800,000 square feet of space to accommodate a fast-growing staff.

Amgen swings for EU approval with its new kidney drug

Amgen filed a European application for etelcalcetide, an intravenous drug for kidney dialysis that the company believes can usurp its own Sensipar.

Regeneron team IDs a candidate for ultra-rare bone disease

Back at the beginning of 2014, a fast-growing Regeneron revealed that it had been building a new genetics research center that would zero in on carefully targeted diseases as it built new drug development programs from the ground up. Eighteen months later the big biotech says the effort--led by some top researchers wooed in to run the operation--has paid off with a clear target for a rare genetic bone disease. And they have an antibody in preclinical testing that could correct the disorder.

Acadia finally delivers long-delayed application for 'breakthrough' Parkinson's drug

Six months after disappointing investors with the latest delay in their FDA application for a new Parkinson's drug, San Diego-based biotech Acadia says it's handed over the package to regulators and decided to give interim CEO Steve Davis the top job on a permanent basis.

Mapi Pharma makes third attempt to list on Nasdaq

Having tried and failed twice to pull off an IPO on Nasdaq, Israeli biopharma Mapi Pharma has arrived on Wall Street yet again in pursuit of $57.5 million (€51.2 million) to funnel into development of its once-a-month version of Teva's Copaxone.

Novartis team tracks remissions of 4-plus years in a pioneering CAR-T study

Five years after the University of Pennsylvania began recruiting a small group of 14 patients with hard-to-treat chronic lymphocytic leukemia, researchers are still tracking three of them who are still alive with no signs of their cancer returning after being treated with a first-generation CAR-T therapy.

Sage sees a future in tremor treatment after a 'probe' study

Sage Therapeutics is pressing forward in the field of tremor treatment after its lead drug notched a positive--though not statistically significant--effect on the debilitating condition in Phase II, results the company believes will help light the way for a bigger trial.

Celyad set to scale up China-focused R&D activities after linking with Medisun

Cell therapy specialist Celyad is set to add Hong Kong to the clinical trial program of its ischemic heart failure treatment, giving its newly recruited partner Medisun data to support an attempt to crack the potentially lucrative Chinese market.

LimmaTech sets up as de facto GSK vaccine R&D unit in wake of $190M buyout

LimmaTech Biologics, a spillover from the $190 million (€169 million) takeover of GlycoVaxyn by GlaxoSmithKline, has opened its doors. The biotech is starting life with GlycoVaxyn's research operation and a 5-year agreement to pump novel bioconjugate antigen‐based vaccines into GSK's pipeline.

Cortendo swings for $86M IPO to fuel late-phase orphan drug R&D drive

Swedish-American biotech Cortendo is pitching to raise $86 million (€76 million) on Nasdaq to pump into a pair of late-phase trial programs, the more advanced of which could lead to a regulatory submission in the back half of 2017.

After partnering with Big Pharmas, Incyte bags its own PD-1 drug in $795M deal

After signing up for combo studies with all the leaders in the checkpoint inhibitor race, Incyte has found a checkpoint program for itself.

Report: Baxalta's $2B plot to buy Ariad broke down over price

Last week's buzz that Baxalta, angling to shake off some unwanted buyout attention from Shire, had set sights on Ariad Pharmaceuticals sent the latter company's shares soaring. But negotiations between the two have since fallen apart, according to Bloomberg.

Adaptimmune pockets GSK payouts after tripling size of TCR trial

Adaptimmune has bagged two milestones from GlaxoSmithKline. The checks landed in Adaptimmune's bank account after it tripled the size of a Phase I/II synovial sarcoma trial of its NY-ESO-1-targeting T-cell receptor (TCR) therapy on the strength of data from the initial cohort.

Tesaro gets a green light for rolapitant, triggering Merck showdown

The FDA has given Tesaro a green light to start marketing rolapitant to help prevent some of the common side effects of chemotherapy. And now Tesaro will wage a David-vs.-Goliath battle for market share with a dominant Merck.

Shire and Sangamo break up their gene-editing partnership

Shire and Sangamo Biosciences are going their separate ways after three-plus years of collaboration in gene editing, with each company hanging on to the programs best aligned to its goals.

Amgen's bone drug beats Lilly's Forteo in a Phase III osteoporosis trial

Amgen's investigational bone-growing drug met its main goal in a late-stage trial, clearing its first Phase III hurdle by besting an Eli Lilly blockbuster for osteoporosis.

AstraZeneca backs $80M round for ADC's antibody warhead tech

In June, Chris Martin took the helm at Spirogen spinoff ADC Therapeutics, where he's been working on a next-gen armed antibody pipeline. And he's just followed up with a whopping $80 million venture round that's designed to get the cancer company through the next three years--and possibly on into an IPO along the way.

In neuroscience swap, Amgen buys into Novartis' BACE drug program for Alzheimer's

Amgen is buying into Novartis' early-stage BACE program for Alzheimer's, paying an unspecified upfront and milestones in exchange for a cut of the program, which looks to slash the production of a key toxic protein widely viewed as a prime suspect in the development of the memory-wasting ailment.

Sanofi punts a $200M Ardelyx deal and hands back some preclinical drugs

Sanofi is backing out of a collaboration with Ardelyx that could have paid out nearly $200 million, returning a handful of candidate treatments for high phosphates in patients with kidney disease.

Trevena rockets up as post-'tummy tuck' pain drug clears Phase II

Trevena's treatment for pain following abdominoplasty met its goals in a Phase IIb study, clearing the way for late-stage development and sending the company's share price soaring.