Topic: synthetic lethality
Repare Therapeutics plans to start testing ATR inhibitor RP-3500 in the clinic next year while putting a second asset through preclinical studies.
With the help of CRISPR, two separate team of scientists have identified a gene essential for the survival of microsatellite instability tumors.
The agreement gives Gilead the option to pick up the worldwide rights to five targets discovered and validated by Tango.
Ideaya expects to get its first synthetic lethality and immuno-oncology assets into human testing in the first half of next year.
Tango uses CRISPR-enabled synthetic lethality to target cancer, but what really sets it apart is its paradigm-shifting approach that puts patient selection before target identification.
CRISPR has made it possible for Repare to increase both the scale and precision of the search for drug targets that can induce synthetic lethality in cancer cells.