Topic: checkpoint inhibitors
The response rate was lower in the ONCOS-102 arm than the control cohort, but Targovax saw positives elsewhere.
VISTA represents a novel checkpoint regulator that can be targeted by both agonists and antagonists to trigger opposing therapeutic T-cell effects.
Sanford Burnham researchers sensitized melanoma to PD-1 blockade by inhibiting a protein called Siah2 in mouse models of the disease.
The deal gives BeiGene the chance to combine Leap’s anti-DKK1 antibody with its recently approved anti-PD-1 checkpoint inhibitor.
Blocking the immune-suppressing enzyme CD73 in mouse models of glioblastoma improved survival among animals given checkpoint inhibitors.
Lowering neutrophil levels in mouse models of non-small cell lung cancer improved responses to PD-1 inhibitors, a Fred Hutchinson team discovered.
Allen Yang, M.D., Ph.D., will now oversee clinical development and operations as Xencor pushes a suite of bispecific antibodies through the clinic.
2019 was something of an annus horribilis when it came to trying to find new therapies for aggressive brain cancer glioblastoma multiforme, and one of the biggest disappointments came from the failure of an immuno-oncology approach to the disease.
ImCheck will use the money to move its lead candidate into the clinic in patients with solid and hematological cancers.
Immunitas Therapeutics is launching with $39 million in series A financing to propel at least one monoclonal antibody into the clinic.