Obeticholic acid (OCA), Intercept Pharmaceuticals

Drug: Obeticholic acid (OCA)
Company: Intercept Pharmaceuticals
Phase: Phase III
Class: Farnesoid X receptor (FXR) agonist
2020 sales: $2.99 billion
Net present sales: $11.4 billion

Shares of Intercept Pharmaceuticals ($ICPT) went into overdrive at the beginning of the year, soaring more than 250% on the surprise news that a Phase IIb clinical study for its lead drug funded largely by the NIH ended early after achieving the primary endpoint. Then after momentarily rattling investors with a report on some serious side effects, the biotech bounced back with upbeat data from its Phase III for primary biliary cirrhosis, setting the stage for a regulatory filing. The bile acid analog--which mimics human bile acid and is an agonist for the farnesoid X receptor--is in development for PBC, nonalcoholic steatohepatitis and other liver and intestinal diseases.

For more:
Intercept grabs the spotlight at EASL, builds case for lead drug OCA
Intercept scores a PhIII win for lead drug following Friday night frights
Intercept shares dazzle after early success of PhIIb liver disease drug trial

Obeticholic acid (OCA), Intercept Pharmaceuticals

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