8. Boston Scientific

2013 med tech R&D budget: $861 million
Change from 2012 budget ($886 million): -2.8%
Percent of segment net sales ($7.14 billion): 12.1%

Boston Scientific ($BSX) is continuing its restructuring, which has trimmed the company's R&D budget from $895 million in 2011. The company expects savings of $150 million to $200 million by the end of 2015. Boston Scientific had 4,000 employees in clinical, R&D and research roles in 2013, the same as in 2012, according to annual reports.

Cardiology and vascular devices remains its major focus. Earning FDA approval of the less invasive CE-marked Lotus Valve System TAVR for patients too frail for open heart surgery is a priority for the company. Boston Scientific released trial results at this year's EuroPCR meeting showing that only 1.1% of patients using the device had moderate paravalvular aortic regurgitation after 6 months and recently created a postmarket registry of patients in Europe. The company also launched the Promus Premier drug-eluting stent in Japan and won FDA approval for a crop of implantable defibrillators in April.

In addition, Boston Scientific invested an undisclosed sum in California-based Amaranth Medical, as the race to be the first to secure FDA approval of a bioresorbable stent heats up. Amaranth's goal is to win a CE mark for a drug-eluting version of its product.

To bulk up in peripheral interventions, Boston acquired Bayer's interventional division for $415 million. In October 2013, the company began clinical trials of its investigational drug-eluting stent Innova for the treatment of superficial femoral artery lesions.

Neurology is another area of focus. The company is ramping up its neuromodulation efforts with a new clinical trial of its implantable deep brain stimulation device for patients with Parkinson's disease.

Finally, although the prospects for renal denervation appear gloomy in the wake of Medtronic's ($MDT) unsuccessful clinical trial of its Symplicity device, Boston Scientific CEO Mike Mahoney said the company plans to forge ahead with its effort to develop a renal denervation device to treat U.S. patients with uncontrolled hypertension. -- Varun Saxena (email | Twitter)

Special Report: Med Tech's 2012 R&D big spenders - Boston Scientific

For more:
Boston Scientific: Lotus TAVI meets endpoint in clinical trial
Boston Scientific to buy Bayer's device unit for $415 million
Boston Scientific rolls out next-gen stent system in Japan
Boston Scientific's CEO signals green for a renewed hypertension push
Amaranth's dissolving cardiac stent drives $25M fundraising round

8. Boston Scientific