Zurich investigators ID pathway for B cell lymphoma

A group of investigators at the University of Zurich say that they have identified a key signaling pathway for B cell lymphoma, adding that experimental drugs now in the clinic are already designed to target it. Their work "revealed eight regions on the DNA, so-called gene loci, that were all abnormally hypermethylated and turned out to be important for the cells' survival. "Follow up experiments revealed one locus in particular that is blocked in almost all the lymphoma patients examined due to DNA methylation and therefore cannot be translated into protein," sums up principal investigator Anne Müller. Release


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