Scientists leverage cell stress to defeat cancer drug resistance

Scientists from Cincinnati Children's Hospital Medical Center report that the best way to prevent breast cancer from growing resistant to therapies may be to genetically strip cancer cells' natural defenses against intrinsic stress. "We leverage the fact that tumor progression essentially is an evolutionary process. Our findings highlight the feasibility of maximizing cell stress by inhibiting adaptive pathways to cause cell death," says Kakajan Komurov. Their results were published May 26 in Science Signaling. Release

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