New FL118 formulation may prove effective against colon, head/neck, mesothelioma, ovarian and pancreatic cancers
BUFFALO, NY — Researchers at Roswell Park Cancer Institute<http://www.
In their previous research, a team led by Fengzhi Li, PhD<http://www.roswellpark.
Comparing the antitumor efficacy and therapeutic index, or relative toxicity, of FL118 in its new intravenous (IV) formulation with the earlier form, the researchers found that maximum tolerated dose increased three- to seven-fold, depending on dosing schedule. While the original formulation contained Tween 80 or polysorbate 80, a solvent commonly included in drug formulations, the agent in its new composition is free of Tween 80, resulting in significantly lower toxicity.
FL118 is a targeted therapy that selectively inhibits the expression of four major cancer-survival gene products: survivin, Mcl-1, XIAP and/or cIAP2. While both studies tested the agent's effectiveness against models of head-and-neck and colon tumors, other research from Dr. Li's lab suggests that mesothelioma, ovarian and pancreatic cancers, and potentially other solid tumors, may also be good targets for treatment with FL118.
"This work represents a significant move forward," notes Dr. Li, senior author on the study. "We're targeting four of the most resilient and pervasive cancer survival mechanisms, and because the findings from preclinical testing have been so striking, we're anxious to see FL118 tested in the clinical setting."
Xiang Ling, MD, PhD, a senior scientist in RPCI's Department of Pharmacology & Therapeutics, is co-author of the paper, "An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)." The study was e-published today and is available at http://goo.gl/y0oZy.
The work was supported in part by grants from the U.S. Department of Defense (PC110408), Mesothelioma Applied Research Foundation and Roswell Park Alliance Foundation<http://www.
The mission of Roswell Park Cancer Institute (RPCI) is to understand, prevent and cure cancer. RPCI, founded in 1898, was one of the first cancer centers in the country to be named a National Cancer Institute-designated comprehensive cancer center and remains the only facility with this designation in Upstate New York. The Institute is a member of the prestigious National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers; maintains affiliate sites; and is a partner in national and international collaborative programs. For more information, visit RPCI's website at http://www.roswellpark.org, call 1-877-ASK-RPCI (1-877-275-7724) or email [email protected]<