Replacing testosterone among aging men has been associated with a number of side effects. But a team at the University of Tennessee says the best approach may be pursuing new drugs that restore the body's ability to make testosterone naturally. Comparing one drug used to restore ovulation in women, the investigators say their approach could also be accomplished without the loss of male fertility as seen in the use of topical therapies. "One of the basic tenets in medicine is to do no harm. As this study has shown in a randomized, double-blind, double-dummy, placebo-controlled manner, exogenous testosterone therapy with Androgel can clearly decrease sperm production and potentially impact fertility," said Edward Kim, a urologist at the University of Tennessee Medical Center. "This study confirmed that Enclomiphene can maintain spermatogenesis while restoring testosterone levels to normal." Release