Purdue group finds Achilles' heel for MERS

Researchers at Purdue University say they have identified molecules that can shut down a key enzyme needed by the Middle East respiratory syndrome, or MERS, virus. "This enzyme is a prime target--an Achilles' heel of the virus--and we were excited to find an inhibitor that worked, but we were puzzled by the results," said team leader Andrew Mesecar. "The behavior was very different from what our work with SARS and other related coronaviruses predicted. So, we investigated what was happening in order to put together the whole story. Now we have new, valuable information for the scientific community working on MERS." A new outbreak of MERS has raised alarms around the globe. Release

Suggested Articles

Brigham and Women’s Hospital scientists linked a noncoding RNA to atherosclerosis in a discovery that could aid in the development of new heart drugs.

Researchers discovered that inactivating a subtype of the protein beta-arrestin-2 in mice restored the ability of the brain to dispose of toxic tau.

A newfound link between BMAL1, a protein involved in circadian rhythms, and triple-negative breast cancer could point to new treatment strategies.