Princeton research could speed pharma discoveries

Princeton University researchers have developed a technique for testing chemicals with an eye toward "accelerated serendipity" in making key discoveries. The method involves the use of robotics to complete more than 1,000 chemical reactions a day with novel molecular combinations, shedding light on speedy ways to form drug-like compounds. "Instead of having to construct these important molecules circuitously using lots of different chemistry over a period of days if not weeks, we can now do it immediately in the space of one chemical reaction in one day," said David MacMillan, the James S. McDonnell distinguished university professor of chemistry at Princeton. Article

Suggested Articles

Removing the IRE1-alpha gene from beta cells in mouse models of Type 1 diabetes restored normal insulin production, scientists found.

Selectively targeting TGF-beta1 with Scholar Rock's SRK-181 overcame primary resistance to checkpoint inhibitor therapy in mice.

Enhertu produced a 55.6% objective response rate in HER2-positive non-small cell lung cancer patients in a phase 1 trial.