Nanomaterials incarcerate prostate cancer cells

Scientists have stopped prostate cancer stem cells (CSCs) in their tracks by incarcerating them inside self-assembling nanomaterials made of peptides, giving researchers hope that the trapped cancer cells can then be targeted for additional treatment with the assurance that they won't get away.

The international team of researchers built and tested the nano-sized traps and published their results in a recent issue of Cell Transplantation. "In this study, we have shown that prostate CSCs can be placed into stasis for an extended period of time without causing them to differentiate," study corresponding author Dr. Rutledge Ellis-Behnke was quoted as saying in Drug Discovery & Development. "If cells are prevented from migrating away from the treatment, they could be subjected to additional targeting."

DD&D reports this research "provides solid evidence" that CSCs may exist within tumors and might be responsible for some treatment failures, since they might be resistant to chemotherapy drugs. The authors speculated that by injecting the material directly into the tumor, it may be possible to stop the spread of metastatic cells, according to the report.

- read the report in Drug Discovery & Development
- or the abstract, with link to free full text, in the journal Cell Transplantation

Suggested Articles

Compass' CD137 agonist cleared large tumors in mice that other I-O agents had failed to treat. It's advancing the drug into phase 1 human trials.

UPMC researchers are planning clinical trials of a COVID-19 vaccine that uses pieces of the virus' spike protein to create immunity.

Treating mice with niacin increased the number of immune cells in glioblastomas, reducing tumor size and extending survival.