MD Anderson spotlights role of cytokine in tumor progression

There's a well-known link between the activation of epidermal growth factor receptors (EGFR) and tumor progression. Now scientists at MD Anderson in Texas can be shut down with the help of a cytokine called macrophage migration inhibitory factor, or MIF. "MIF can be secreted from both tumor and immune cells," said Zhimin Lu, M.D., Ph.D., professor of Neuro-Oncology. "Importantly, secreted MIF is modified by an attached sugar group which allows MIF to gain a specific new function compared to its non-modified form." Release