Genetic variation key indicator of diabetes risk

A common genetic variation may be more significant than obesity as an indicator that a person is at risk of developing type 2 diabetes, according to a team of UK researchers. The team found that people with two copies of the mutant TCF7L2 gene were twice as likely to develop type 2 diabetes as people with no copies. The researchers tracked the cases of 2,676 European middle-aged men who have been evaluated over a period of 15 years. Out of that group, 158 developed type 2 diabetes. Those with one variant of the TCF7L2 gene were 50 percent more likely to develop diabetes while those with two copies were 100 percent more likely.

"Although being overweight is the major risk factor for developing diabetes, it is now becoming clear that an individual's genetic makeup has a big impact on whether or not they are going to develop diabetes," Professor Steve Humphries, lead researcher on the study from the University College London Centre for Cardiovascular Genetics told the BBC.

- check out the report on the issue from the BBC

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