Enzyme in mice linked to obesity, diabetes

Following the theory that Type 2 diabetes is triggered by inflammation, a group of researchers at the German Cancer Research Center concluded that turning off the enzyme Kit prevented a cascade of metabolically linked pathogenic processes. Targeting Kit in mice prevented them from gaining weight and guarded them against insulin resistance. And they're focused on finding the immune cells that produce Kit. "Now we know the key molecule involved in the development of pathogenesis. But we still have to find out which of the various immune cell types are actually involved," says Professor Hans-Reimer Rodewald. Release

Suggested Articles

A newfound link between BMAL1, a protein involved in circadian rhythms, and triple-negative breast cancer could point to new treatment strategies.

Combining a DYRK1A inhibitor with popular GLP-1 receptor agonists regenerates insulin-producing beta cells, Mount Sinai scientists found.

Arming a peptide taken from the virus that causes foot-and-mouth disease in cows with the payload tesirine shows promise against pancreatic cancer.