Enzyme in mice linked to obesity, diabetes

Following the theory that Type 2 diabetes is triggered by inflammation, a group of researchers at the German Cancer Research Center concluded that turning off the enzyme Kit prevented a cascade of metabolically linked pathogenic processes. Targeting Kit in mice prevented them from gaining weight and guarded them against insulin resistance. And they're focused on finding the immune cells that produce Kit. "Now we know the key molecule involved in the development of pathogenesis. But we still have to find out which of the various immune cell types are actually involved," says Professor Hans-Reimer Rodewald. Release

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Five Translational Insights Key to a Successful First-in-Human (FIH) Study – Metabolite-Based Biomarker Discovery and Validation

Translational success rates from pre-clinical animal studies to human clinical trials remain frustratingly low. Learn how metabolomics helps you bridge between the theoretical & practical, between the function & actual activity of your drug molecule to get you closer to the phenotype, sooner.