Brown U team pinpoints new drug target

Investigators at Brown University have stripped down a kinase complex, developing a detailed analysis of its structure that led them to a potential new drug target. "Disregulation always leads to disease," said Wolfgang Peti, associate professor of medicine and chemistry at Brown University and senior author of a paper published online Nov. 6 in Nature Chemical Biology. "To make better drugs, what we want to do is look for individual things that are different between different complexes. The problem is we didn't know where those non-common spots are. We didn't have the structures that tell us the story. We were the first to get one of those structures." Release

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