A key to blocking fever, symptoms

New insights into the way the brain operates are opening up a new therapeutic target to control fever as well as many of its symptoms like fatigue and loss of appetite. Researchers at Harvard Medical School's Beth Israel Deaconess Medical Center in Boston have found the precise cells in the brain that spur a rise in body temperature in reaction to inflammation. Once fever occurs, the body releases prostaglandins which bind to EP3 receptors in the hypothalamus region of the brain. By deleting the gene for the receptors, which the team accomplished in mice, they prevented the development of fever. They believe new drugs could be used to knock out specific symptoms, such as achiness or loss of appetite or just feeling crummy. In diseases like Crohn's or arthritis, the fever itself could be blocked.

- see the release on the research
- here's the report from The New York Times

Suggested Articles

Compass' CD137 agonist cleared large tumors in mice that other I-O agents had failed to treat. It's advancing the drug into phase 1 human trials.

UPMC researchers are planning clinical trials of a COVID-19 vaccine that uses pieces of the virus' spike protein to create immunity.

Treating mice with niacin increased the number of immune cells in glioblastomas, reducing tumor size and extending survival.