Mouse model could have predicted drug toxicity that killed 5 in clinical trial

In a 1993 clinical trial of fialuridine--a drug originally designed as a therapy for hepatitis B--5 out of 15 patients died from sudden liver failure. A new study in PLOS Medicine found that mice with humanized livers demonstrate the drug's toxicity. The research suggests that the mouse model could have predicted the toxicity of the drug, and the study authors believe the model should be used in preclinical screening of drugs for liver toxicity before they are given to human participants in clinical trials. Study

Suggested Articles

A new study suggests that biosimilars for a class of biologics called TNF-α inhibitors are as safe and effective as their brand-name counterpart.

A decade of flat funding compounded by last year's federal sequester cuts has put U.S. biomedical research in a pinch in recent years, but under a new…

An in vitro technique using samples of beating heart tissue may be able to to test the effects of drugs on the heart without unnecessary testing on humans or…