Roche eyeing buyouts of $7B-plus; Survey: Devicemakers mulling tax-prompted layoffs in 2013;

 @FierceMedDev: DioGenix Series B funds crucial trial for MS Dx. Story | Follow @FierceMedDev

@MarkHFierce: A Novartis subsidiary is licensing Trovagene's find that a certain protein, found in urine, can indicate leukemia. News | Follow @MarkHFierce

 @DamianFierce: Privately held CardiacAssist is targeting the heart pump market after getting FDA OK for a pivotal trial. More | Follow @DamianFierce

> Roche ($RHHBY) still has its eye on a gene sequencing acquisition, and CFO Alan Hippe told Bloomberg the drug and diagnostics giant is looking at deals $7 billion and above. Article

> Canada's Angiotech got the FDA's OK to market the Bio-Seal Lung Biopsy Tract Plug System, a device designed to help diagnose lung ailments by filling biopsy punctures. Release

> Two Mumbai hospitals are the first in India to start using bioresorbable stents made by Abbott Laboratories ($ABT). Story

> More than half of medical device startups surveyed by the National Venture Capital Association say they expect funding to keep declining in 2013. Most startup CEOs say they see themselves being acquired rather than pursuing an IPO. Story

> Molecular diagnostics company CombiMatrix ($CBMX) says it has regained full compliance with NASDAQ's minimum bid requirements for listing. Item

> A new AdvaMed member survey reveals expectations of between $400 million and $667 million to implement the device tax, with 62% of respondents expecting the tax will force layoffs or reduced hiring. Story

> Diagnostic heavyweights Illumina ($ILMN) and Life Technologies ($LIFE) have found a new market for their products: Dairy farmers looking to predict which bulls will breed the best milking cows. Story

Biotech News

 @FierceBiotech: Nuron Biotech bags $80M deal to back vaccines portfolio, PhIII multiplesclerosis drug work. Story | Follow @FierceBiotech

@JohnCFierce: Tredaptive failure likely to leave a mark at Merck, which spends more than $8B a year on R&D. This could trigger a reorg. News | Follow @JohnCFierce

@RyanMFierce: Biogen is teaming up on ALS research w/ experts @ Yale Harvard & Columbia, committing $10M+, as its ALS rx is in P3. Release | Follow @RyanMFierce

> Roche's sweet spot: The $6B-$7B acquisition deal. Item

> Investors gamble $75M on Ultragenyx's plan to jump-start rare-disease player. Report

Pharma News

@FiercePharma: Judge thwarts Endo's effort to block non-tamper-resistant copies of Opana ER. FDA still might, tho. More | Follow @FiercePharma

> Sanofi settles Hyalgan kickback probe for $109M. Report

> CFO: No stock buybacks for Roche. Let's make a $7B deal instead. News

> Amgen whistleblower went undercover for the feds. Story

Pharma Manufacturing News

> Novartis to buy Dendreon New Jersey plant. Article

> Hot for fish oil, BASF expands plant, pursues Pronova. News

> India API makers complain about cheap Chinese imports. Story

Vaccines News

 @AlisonBFierce: India is cruising along in the vaccines market. A WHO clearance will hoist the country's vaccine exports. More | Follow @AlisonBFierce

> WHO clearance to hoist Indian vaccine exports. Report

> GSK teams with GlycoVaxyn to develop anti-bacterial vaccines. Article

> U.N. contemplates ban on vaccine preservative. News

> FDA approves GSK's quadrivalent flu vaccine. Story

> Georgia State scientists investigate universal flu vaccine. More