Computer-aided method could lead to early diabetic retinopathy diagnostic

Diagram of eye

IBM developed a method combining deep learning and visual analytics to detect and gauge the severity of diabetic retinopathy from an eye image. The team found their method beat out other published efforts that use deep learning.

People with diabetes may develop diabetic retinopathy, where high blood sugar levels damage blood vessels in the retina. These vessels may swell and leak, or close, stopping blood flow altogether, according to the American Academy of Ophthalmology.

The leading cause of blindness among diabetics, diabetic retinopathy is classified into five levels of severity. If left untreated, it can cause permanent blindness, but early detection is crucial in warding off vision loss.


Like this story? Subscribe to FierceBiotech!

Biopharma is a fast-growing world where big ideas come along every day. Our subscribers rely on FierceBiotech as their must-read source for the latest news, analysis and data in the world of biotech and pharma R&D. Sign up today to get biotech news and updates delivered to your inbox and read on the go.

"To substantially reduce the number of people unnecessarily losing vision from diabetic eye disease, there is a real need for innovation to improve effective screening of those who are at risk to enable early sight-saving treatment,” said Peter van Wijngaarden, principal investigator at the Centre for Eye Research Australia at University of Melbourne, in a statement.

Using more than 35,000 eye images, the IBM team trained the technology to identify different types of lesions and assess the extent of the damage to the retina’s blood vessels, IBM said in the statement. These included micro-aneurysms and hemorrhages, which can indicate the presence and severity of diabetic retinopathy.

The method, which uses deep learning, convolutional neural networks (CNN) and dictionary-based learning, was accurate 86% of the time in classifying the severity of the disease. The scale ranges from no diabetic retinopathy to mild, moderate, severe and proliferative diabetic retinopathy.

Related: IBM Watson, ADA partner to apply cognitive computing to diabetes clinical and research data

IBM’s algorithm analyzes images pixel by pixel and patch by patch, said IBM’s Rahil Garnavi in a blog post. It “learns patterns associated with a particular pathology and disease,” she wrote. As the tech churns through more images, it will get better and better at differentiating between the different levels of severity.

The disease is currently diagnosed using fundus photography of the retina—a clinician manually examines these images to spot lesions. But this is often a time-consuming and subjective process. A computer-aided method that quickly and accurately classifies the severity of the disease could also standardize the interpretation of eye images.


Suggested Articles

By employing heart rate signals, physical activity and sleep quality, common Fitbit trackers may be able to predict the spread of the flu.

Nanox has raised $26 million to help fuel the development and commercialization of its Star Trek-inspired digital X-ray bed.

Oncology is clearly a major medical and societal issue, but one that sees too much focus from biopharmas at the expense of other killers.