The FDA has ordered drug makers to stop making anti-nausea suppositories that contain the active ingredient trimethobenzamide, saying they are ineffective. The move is part of a wider effort by the FDA to take a second look at drugs approved before 1962, when developers had to prove that a drug would do no harm as the main condition for approval. Some two million of the suppositories are sold each year. The agency estimates that there are several hundred unapproved active ingredients in use today. Report