Shire extends RNA research deal with Santaris; InVivo names Astrue interim CEO; Mayo Clinic to open stem cell lab;

@FierceBiotech: Shire and Santaris extend their strategic alliance to discover, develop LNA-drugs in the rare disease field. Press release | Follow @FierceBiotech

@JohnCFierce: The latest on the Onyx buyout: Yes they are. No they aren't. Say what? Item | Follow @JohnCFierce

@EmilyMFierce: This week's career moves in biopharma. Chutes & Ladders | Follow @EmilyMFierce

> In another indication that RNA is back in vogue, Shire ($SHPG) has extended its collaboration with Santaris Pharma on RNA-targeted therapies in the rare genetic disease arena. Santaris received an unspecified upfront in the deal. Release

> Cambridge, MA-based InVivo Therapeutics says that Francis Reynolds has resigned as chairman and CEO due to his medical condition and is being replaced on an interim basis by Michael Astrue, the non-executive chairman at Vivus. Report

> The Mayo Clinic plans to open a stem cell lab in Phoenix. Story

> Nuvilex, a penny stock company with a market cap of $74 million, says it is restructuring its business around its biotech assets. Release

> Ireland's Trinity Biotech acquired Buffalo, NY-based IMMCO Diagnostics for $33 million. Story

Pharma News

@FiercePharma: Merck has the Zilmax PR right: Animal advocate Temple Grandin to consult on livestock drug's safety. More | Follow @FiercePharma

@EricPFierce: Regeneron takes a "byte" out of excess manufacturing capacity in Ireland. ICYMI yesterday | Follow @EricPFierce

@CarlyHFierce: Amid Purdue criticism, CVS cuts opioid access for 'risky' prescribers. ICYMI yesterday | Follow @CarlyHFierce

> Takeda presses on in emerging markets with Peru operation. Story

> SAC fund manager alleged to have not 1 but 2 docs feeding him insider info. More

Medical Device News

@FierceMedDev: Bard settles vaginal mesh suit as thousands pend. ICYMI yesterday | Follow @FierceMedDev

@DamianFierce: Israel's InSightec is expanding into Canada with its surgery-free uterine fibroid treatment. News | Follow @DamianFierce

@MarkHFierce: We're launching a new diagnostics report in less than a week, and I'll be writing it. Sign up here | Follow @MarkHFierce

@MichaelGFierce: FDA clears Novo Nordisk's insulin injection pen for children. Item | Follow @MichaelGFierce

> KKR, Bain said to bid for Panasonic's billion-dollar health unit. Article

> A first: Medtronic co-founder absent from annual meeting. Item

And Finally… Investigators say that receptors called heparan sulfate proteoglycans (HSPGs) help the spread of Alzheimer's and Parkinson's, offering a new target for drug developers. Release

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